NODOVOX | Discovery

Exploring the antimicrobial and pharmacokinetic properties, molecule docking of newly synthesized indole-thiadiazole derivatives

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Exploring the antimicrobial and pharmacokinetic properties, molecule docking of newly synthesized indole-thiadiazole derivatives

Nishan S. Gadara et al · Springer · 2026 · ISSN 3005-1193

Abstract The present study employed a three-step synthetic strategy to develop a series of novel (Z)-N-(2,4-dimethylphenyl)-3-(3-(((5-phenyl-1,3,4-thiadiazol-2-yl) imino) methyl)-1H-indol-1-yl) propanamide derivatives. T...

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Network pharmacology, pathway enrichment, and molecular docking analysis reveal the multi target therapeutic potential of phytochemicals from Eleusine coracana

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Network pharmacology, pathway enrichment, and molecular docking analysis reveal the multi target therapeutic potential of phytochemicals from Eleusine coracana

Amisha Bisht et al · Springer · 2026 · ISSN 3005-1193

Abstract Eleusine coracana (L.) Gaertn., commonly known as Ragi or finger millet, is a nutrient-rich cereal traditionally valued for its health-promoting properties. However, its precise molecular mechanisms and therapeu...

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Traditional rice landraces disrupt Spodoptera litura reproduction: biochemical profiling and molecular docking

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Traditional rice landraces disrupt Spodoptera litura reproduction: biochemical profiling and molecular docking

Subbu Thavamurugan et al · Springer · 2026 · ISSN 3005-1193

Abstract Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) is a major pest that causes great damage and loss economically in the cultivation of rice. To evaluate rice's potential for resistance to S. litura, fourth-...

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Design, synthesis, characterization, in-silico and in-vitro evaluation of novel 2-mercapto benzimidazole derivatives tethered with isoniazid for the treatment of tuberculosis

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Design, synthesis, characterization, in-silico and in-vitro evaluation of novel 2-mercapto benzimidazole derivatives tethered with isoniazid for the treatment of tuberculosis

Nayana Ravindra Jawale et al · Springer · 2026 · ISSN 3005-1193

Abstract 2-Mercapto benzimidazole derivatives are well-recognized for their diverse pharmacological activities, including anti-tubercular, antimicrobial, anti-ulcer, analgesic, and anticancer properties. Isoniazid, a fir...

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Molecular modelling and cytotoxic activity of donor-π-acceptor fluorescent diphenylamino-thiazole chromophores

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Molecular modelling and cytotoxic activity of donor-π-acceptor fluorescent diphenylamino-thiazole chromophores

Shadiah Albalawi et al · Springer · 2026 · ISSN 1319-6103

Abstract Three chromophores 5a-c based on the diphenylamine (donor), thiazole (π-core) and acrylonitrile (acceptor) were synthesized and characterized by IR, NMR, MS analyses. The donor–acceptor chromophores 5a-c were...

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Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma

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Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma

Ruixiang Li et al · Springer · 2026 · ISSN 2730-6011

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...

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Integrated analysis of Morusin inhibiting esophageal cancer via network pharmacology molecular dynamics simulation and in vitro validation

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Integrated analysis of Morusin inhibiting esophageal cancer via network pharmacology molecular dynamics simulation and in vitro validation

Miyuan Yang et al · Springer · 2026 · ISSN 2730-6011

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

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Integrative network pharmacology and in vitro validation reveal the mechanisms by which Apigenin reverses MET-TKI resistance in non-small cell lung cancer

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Integrative network pharmacology and in vitro validation reveal the mechanisms by which Apigenin reverses MET-TKI resistance in non-small cell lung cancer

Xiaofei Li et al · Springer · 2026 · ISSN 2730-6011

Abstract Objective This study aimed to elucidate the molecular mechanisms by which Apigenin (APG) reverses MET-TKI resistance in non-small cell lung cancer (NSCLC). Methods Network pharmacology and molecular docking were...

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Synergistic Effects of Urban Air Pollution Mixtures on AMD Pathogenesis: Subtype-Specific Molecular Signatures and Predictive Modeling

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Synergistic Effects of Urban Air Pollution Mixtures on AMD Pathogenesis: Subtype-Specific Molecular Signatures and Predictive Modeling

Meilan Chen · Springer · 2026 · ISSN 1680-8584

Abstract Industrialization and urbanization exacerbate global environmental health challenges, with pollutants from industrial and vehicular emissions (e.g., PAHs, NOx, PM2.5) posing significant risks. Growing evidence l...

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