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Abstract N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA and plays a crucial role in post-transcriptional gene regulation. Recent studies have revealed that m6A modification is dysr...

Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...

Abstract Background Lung cancer remains the leading cause of cancer-related mortality worldwide. This study aimed to develop prognostic prediction models for lung squamous cell carcinoma (LUSC) through multi-omics integr...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

Abstract Objective To explore new diagnostic markers and therapeutic targets associated with the histological types of thymoma. Methods The TCGA and GEO was used to gather genomic and clinical data from thymoma patients....

Abstract Ornithine lipids (OLs) are phosphorus-free membrane lipids present in many bacteria, but absent from eukaryotes and archaea. Three pathways for OL synthesis have been reported to date. Conditions that induce OL ...

Abstract Background  The genomic and epigenetic landscape of the gasdermin family across cancers, and its clinical relevance, remain incompletely defined.  Methods Multi-omics features of gasdermins across 33 cancer ty...