NODOVOX | Discovery

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

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BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Han Leng Ng et al · Wiley · 2026 · ISSN 2198-3844

ABSTRACT Cancer is driven by genomic lesions and malignancy‐promoting transcriptional programs. In blood cancers, both are often interconnected as lesions frequently affect transcription factor (TF)‐encoding genes. T...

LCC TENDOlNjaWVuY2U~Idioma eng

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Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

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Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

Runze Sun et al · Wiley · 2026 · ISSN 2198-3844

ABSTRACT Genome engineering plays a crucial role in the rapidly growing fields of metabolic engineering and synthetic biology. Chromosomal integration and stable expression of functional genes or large metabolic pathways...

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Application of Reinforcement Learning Techniques in De Novo Drug Design: A Systematic Literature Review

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Application of Reinforcement Learning Techniques in De Novo Drug Design: A Systematic Literature Review

Masuda Begum Sampa et al · Wiley · 2026 · ISSN 2398-8835

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer

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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer

Saha Tanmoy et al · Wiley · 2021 · ISSN 2192-8614

Targeted delivery of drugs to tumor cells, which circumvent resistance mechanisms and induce cell killing, is a lingering challenge that requires innovative solutions. Here, we provide two bioengineered strategies in whi...

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Artificial Intelligence and Prostate–Breast Cancer Biology: Recent Advances in Treatments and Perspectives — A Comprehensive Review

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Artificial Intelligence and Prostate–Breast Cancer Biology: Recent Advances in Treatments and Perspectives — A Comprehensive Review

Russell B. O. Ouma et al · Wiley · 2026 · ISSN 2398-8835

ABSTRACT Background and Aims The therapeutic limitations of conventional cancer treatment currently deployed are driving the development and creation of new nano‐drugs. Prostate cancer (PCa) is a prevalent clinical pro...

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