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Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...

Abstract Background Entomological outcomes are critical for understanding the biological mechanisms and operational performance of malaria vector control interventions. However, the quality and consistency of how these o...

ObjectiveTo evaluate the efficacy and safety of skull base-peripheral (SBP) acupuncture in patients with post-stroke cognitive impairment (PSCI).MethodsWe searched eight Chinese and English databases from inception to Ju...

Background Non-scarring alopecia, including androgenetic alopecia, alopecia areata, and telogen effluvium, is highly prevalent and often associated with significant psychosocial burden. Although treatments such as minoxi...

Abstract Background Postpartum depression and anxiety are common and burdensome. Physical activity (PA) is a scalable intervention, yet the comparative effectiveness of PA modalities and optimal dosing in the postpartum ...

Abstract The application of Bayesian statistics in pivotal clinical trials has gained increasing attention, particularly for underpowered confirmatory trials such as those in pediatric and rare disease populations. Bayes...

Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...

Abstract Importance The mortality benefit of lipid-lowering therapies (LLTs) in true primary prevention of cardiovascular disease (CVD) remains uncertain, in part because prior studies frequently included individuals wit...

Abstract Background Subjective cognitive decline and mild cognitive impairment represent critical windows for intervention as early stages of dementia progression. Although digital health interventions have shown potenti...

This systematic review and meta-analysis evaluated pomegranate supplementation effects on blood pressure and endothelial function in adults. Four main databases, including PubMed/MEDLINE, Web of Science, SCOPUS, and Emba...

Abstract Background Diabetic Foot Ulcers (DFUs) represent a global healthcare challenge, imposing substantial socioeconomic burdens due to their increasing incidence and associated mortality. This study evaluates the eff...

Abstract Background Traditional nasal packing following septoplasty imposes significant patient morbidity, including pain, obligate oral breathing, and sleep disruption. Negative pressure drainage (NPD) represents a mech...

ObjectiveThis systematic review and meta-analysis aims to evaluate the effects of Tai Chi Chuan on the expression of pro-inflammatory genes IL-6, IL-1β, and TNF-α—downstream of the NF-κB pathway—in adults with chr...

Abstract Background Traumeel (Tr14) and diclofenac gels are commonly prescribed topical treatments for Grade I-II acute lateral ankle sprain (LAS). A meta-analysis of two multi-center trials was performed to compare thei...

Abstract Background Mosquito movement is ubiquitous and complicates the design of cluster randomized trials (CRTs) of vector control interventions because it can cause spillover between trial arms. There has been no anal...

Abstract Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of childhood-onset inflammatory arthritides that remain challenging to treat. An expanding range of biologic and targeted synthetic disease-mod...

ABSTRACT Background and Aims Propolis is a natural resinous substance produced by bees, recognized for its antioxidant and anti‐inflammatory properties. Previous clinical trials have reported inconsistent results regar...

Abstract This meta-analysis aimed to code active cognitive behavioral elements in mental health apps and to examine the association between these elements and improvements in depression and anxiety. Trials evaluating men...

Abstract Background Adaptive designs (ADs) are increasingly used, whereby outcome data accumulated during the trial may inform a trial’s course in accordance with pre-specified rules at interim analyses. The benefits h...

Abstract Background Randomised controlled trials (RCTs) are often considered the gold standard in research design to determine clinical and cost-effectiveness, and yet the majority are not considered “informative” or...

BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...

Abstract Background Sorafenib has served as standard treatment for advanced hepatocellular carcinoma (HCC). Recently, several randomized controlled trials (RCTs) have explored the use of programmed cell death protein 1/p...

Abstract Background Ureteral double-J (JJ) stents are widely used in endourological practice but are frequently associated with discomfort and stent-related morbidity, particularly during removal. Extraction-string stent...

Objective: To evaluate the efficacy and safety of Ganmai Dazao (GMDZ) decoction alone and in combination with antidepressant medication or psychotherapy for depression. Methods: We searched seven electronic databases fro...