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Acute myeloid leukemia (AML) is the most frequent type of leukaemia in adults, often with poor outcomes due to the complex genetic landscape and low treatment efficacy. Autophagy, a conserved degradation process, plays a...

Background and purpose: Artificial intelligence-based contouring tools enable assessment of radiation doses to cardiac substructures beyond mean heart dose. This study examined inter-solution variations in raw contours a...

HER2 actúa como biomarcador pronóstico y predictivo en cáncer de mama (CaMama) temprano metastásico. Un tumor HER2-positivo tiene IHQ de 3+ o 2+ con amplificación confirmada de HER2 mediante hibridación in situ (IS...

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

Pregnancy is accompanied by complex physiological adaptations that influence hepatic metabolism, bile transport, coagulation, and immune tolerance, which may precipitate the development of pregnancy-specific liver disord...

Background Vaccine hesitancy and public adherence to health measures remain critical challenges in Slovakia, where coverage of COVID-19 vaccination has been low, and parents’ decisions regarding vaccination of their ch...

Em Novembro de 2025, a professora doutora Alexandra Lima da Silva e o professor doutor Ednardo Monteiro Gonzaga do Monti visitaram a Universidad Pedagógica Nacional, em San Luis Potosí – México. Na ocasião, realiza...

Background Antiseizure medications (ASMs) are the standard treatment for epilepsy. Yet because ASMs can have adverse effects and seizure risk decreases with longer seizure-free periods, guidelines have suggested consider...

In this study, the authors show that treatment with acetyl-carnitine can ameliorate learning and memory defects and hyperactivity in a mouse model of the cognitive disorder, Arboleda–Tham syndrome. Pathogenic variants ...

Abstract Electroencephalographic neurofeedback (EEG-NF) has been proposed as a promising technique to modulate brain activity through real-time EEG-based feedback. Alpha neurofeedback in particular is believed to induce ...

Abstract Precision oncology relies on access to high-quality data for increasingly smaller patient subgroups. The international atomCAT consortium investigates the potential of federated learning to support this, using a...

Abstract Background There is little evidence on the association between cooking with polluting fuels, particularly charcoal, and heart disease from low- and middle-income countries, which have the highest burdens of poll...

Abstract Background Social participation, a principle that has guided health reform processes globally, presents diverse barriers according to the political and social context, obstructing its effective exercise. This st...

BackgroundCaffeine is one of the most frequently administered medicines in neonatology—prescribed for the management of apnoea of prematurity, to aid extubation and increasingly for conditions such as bronchopulmonary ...

The present study aimed to investigate the effectiveness of recreational citizen science in biodiversity monitoring. The goal was to evaluate whether a minimal training protocol can maintain data quality while engaging l...

Este estudio analiza la incidencia de las estrategias neurosensoriales en el fortalecimiento de la socialización de niños de 3 a 4 años en la Unidad Educativa Fiscomisional San Carlos Lwanga (Guayaquil), durante el pe...

Abstract Background Early detection of renal involvement in ANCA-associated vasculitis (AAV) is crucial, as functional changes often precede anatomical damage. Current diagnostic standards, such as the measurement of ser...

Thymic stromal cells drive T cell development by supplying key cues for progenitor proliferation and differentiation. Although thymic epithelial cells are well characterized, recent studies highlight crucial functions of...

Abstract Background Biallelic SPG7 mutations cause one of the most common forms of hereditary spastic paraplegia (HSP). Several reports have suggested that heterozygous SPG7 variants may also play a role in HSP, but also...

Abstract Background Suicide rates among U.S. preteens (ages 8–12) have risen steadily since 2008, signaling a growing crisis in children’s mental health. Sexual and gender diverse (SGD) preteens are at especially hig...

Abstract Enhanced weathering in agriculture is a potential gigatonne-scale carbon dioxide removal (CDR) pathway, but its potential remains difficult to constrain. We used a formal expert elicitation process to estimate C...

G-protein coupled receptor 43 (GPR43) mediates the biological effects of short-chain fatty acids (SCFAs) in the colon, but its role in colon cancer (CC) remains insufficiently characterized. This pilot study presents in ...

The accelerating expansion of green investment and climate-oriented finance has intensified scholarly interest in the relationship between financial markets and the energy transition. However, as this literature has ev...