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Objective: To determine the optimal dosing ratio of the herbal components within compound Hemerocallis citrina Baroni (H. citrina) extract concentrate (CHEC), evaluate its antidepressant effects in zebrafish and mouse mo...

Brain-Derived Neurotrophic Factor (BDNF) is the most abundant neurotrophin in the central nervous system with essential roles in neurodevelopment and maintenance of healthy brain function. Accordingly, BDNF has been sugg...

Depression represents a significant global public health problem, negatively affecting patients’ quality of life and social functioning. Despite the increasing availability of effective pharmacological and psychotherap...

Abstract The global rise in mental health conditions has prompted interest in interventions that act beyond conventional psychopharmacology. Psychobiotics, broadly understood as live microorganisms or microbe‐derived p...

Naringenin (NGN), a flavonoid widely utilized in agricultural and pharmaceutical applications, has increasingly become a source of environmental concern. This study systematically evaluated the developmental toxicity of ...

Early adversity programs induce changes that can accelerate biological aging. Using the early stress model of maternal separation (MS), we assessed oxidative, metabolic, and biochemical consequences in serum derived from...

Post-stroke dysphagia (PSD) is a frequent, disabling complication of ischemic stroke. Because acupotomy has limited effects on swallowing and gut–brain axis modulation with probiotics may support neural repair, we perf...

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation, impaired epidermal barrier function, and recurrent episodes of itching and inflammation. Emerging evidence...

Abstract Fecal microbiota transplantation (FMT) has emerged as a novel approach for understanding anorexia nervosa (AN), a complex eating disorder characterized by severe underweight, fear of weight gain and distorted bo...

Abstract Background Endoplasmic reticulum stress (ERS) is linked to the progression of atherosclerosis (AS). The function of ERS-related genes (ERSRGs) in AS remains ambiguous, hence, this study sought to examined their ...

Objective: To investigate the role of PINK1/Parkin-mediated mitophagy in regulating synaptic remodeling of neuronal cells in depression-like behaviors induced by nonylphenol (NP). Methods: In vitro experiments: HT-22 neu...

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...

ObjectiveThis study aimed to investigate the effect of high-frequency transcranial magnetic stimulation (TMS) targeting multiple brain regions on the recovery of consciousness in patients with minimally conscious state (...