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IntroductionAlthough immune responses to Bacillus Calmette–Guérin (BCG) vaccination and susceptibility to mycobacterial infection vary across individuals, the underlying cellular mechanisms regulating this heterogenei...

In severe cases of COVID-19, glucocorticoid treatment improves clinical outcomes. However, in non-hospitalized patients, glucocorticoids have limited benefit and may impair viral clearance. Here, we used the rhesus macaq...

Resumen: Introducción: La incidencia de cáncer de mama (CM) en mujeres jóvenes ha aumentado, pero existen pocos estudios que analicen factores pronósticos en este grupo etario. Métodos: Estudio retrospectivo de pac...

Abstract Background Shigella species are a significant global public health threat with the highest burden of Shigella-associated diarrhoea in children under five years of age, particularly in low- and middle-income coun...

Background This study aimed to analyze the relationship between the level of professional burnout, professional functioning styles, and occupational activity in a group of soldiers and civilian employees working in the m...

IntroductionChlamydia trachomatis (Ct) is the most common bacterial cause of sexually transmitted infection worldwide. Given the limited effectiveness of current Ct screening and treatment programs, alongside the lack of...

Abstract Backgrounds Malnutrition is common among hospitalised older adults, and weight may continue to decline after discharge without nutritional support. Post-discharge home visit programmes by dieticians show positiv...

Objective To examine associations between participants’ perinatal factors, including harmonised birth weight and length, prematurity, exposure to maternal smoking during pregnancy and breastfeeding during infancy, and ...

Storytelling is a fundamental human behavior, and narrative skill is predictive of success in many domains, such that the development of narrative skill is an important process in childhood and adolescence. The goal of t...

Abstract Background It is well-established that cannabis can affect driving in the hours after cannabis use, but the exact duration of these effects, and relationship with delta-9-tetrahydrocannabinol (THC) concentration...

Abstract Background Nutritional status and lifestyle during the preconception phase, the months and years before conception, may have substantial impact on the health of the next generation. Diet quality during these yea...

Background: Social media influencers (SMIs) are critical information sources for beauty and personal care product purchases, yet limited research exists on their effectiveness in emerging markets like South Africa. Exis...

BackgroundEarly complement pathway deficiencies predispose to invasive infections with encapsulated bacteria. C2 deficiency is the most common human complement deficiency, yet it may remain clinically silent until a life...

The global rise of multidrug-resistant bacteria necessitates the development of new antimicrobials and faster diagnostic tools. Conventional antimicrobial susceptibility testing is slow, relying on culture-based methods ...

Abstract Background Epidermolysis bullosa (EB) is a rare genetic disorder that causes extreme skin fragility, chronic pain, and functional impairment, with major psychosocial and economic consequences. Health-related qua...

Abstract Background Despite improvements in pain and function following total knee replacement (TKR), most patients do not achieve recommended levels of moderate-vigorous physical activity (MVPA), putting them at increas...

IntroductionLow T cell receptor excision circles (TRECs) on newborn screen and severe T cell lymphopenia in a term newborn raise concern for severe combined immunodeficiency (SCID). Genetic polymorphisms in thiopurine me...

Abstract Background Cumulus granulosa cells (CGCs) are essential for oocyte support, metabolic cooperation, and steroidogenesis, yet they deteriorate rapidly in conventional 2D culture, limiting long-term studies of thes...

Approximately 20% of Nigerians experience a mental health condition, yet fewer than 10% receive minimally adequate care. This scoping review synthesises the development, implementation and outcomes of mental health polic...

Background HIV is a major health challenge in Kenya, where prevalence exceeds global averages. Achieving viral suppression depends on consistent adherence to antiretroviral therapy (ART), but individuals in neighbourhood...

BackgroundT cell receptor excision circle (TREC)-based newborn screening (NBS) for severe combined immunodeficiency (SCID) has improved early diagnosis, treatment, and survival of SCID infants and identified additional c...

Abstract Background The exponential rise in colorectal cancer surgeries among older adults combined with 30-day readmission rates as high as 25% highlights the crucial need to optimize post-discharge care. While geriatri...

Abstract Background Objective structured clinical examinations (OSCEs) have recently been integrated as one of the academic assessment tools for French undergraduate medical students. Data are scarce regarding the correl...

Abstract Introduction Dyspepsia affects 6.9% of people globally and significantly impairs quality of life, yet it often remains undiagnosed. Undiagnosed dyspepsia (UD) affects up to one-third of patients and is prevalent...