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Abstract Background Research has produced a substantial and expanding body of evidence-based practices (EBPs), encompassing interventions, programmes, clinical guidelines, protocols, care pathways and models of care supp...

Regulatory science governing monoclonal antibody development has undergone a profound transformation over the past decade, shifting from empiricism-driven paradigms toward evidence-efficient, mechanism-based frameworks g...

ObjectiveTo summarize the best evidence for non-surgical intervention in periodontitis among patients with type 2 diabetes mellitus, and to provide a basis for medical and nursing staff to carry out periodontitis managem...

Materias / palabras clave: clinical decision making; evidence based practice; evidence based treatment; intervention planning; treatment planning

ObjectiveChronic pain, a major global public health burden, is primarily driven by altered central pain processing, which conventional treatments rarely target directly. This systematic review and meta-analysis synthesiz...

IntroductionUnderstanding the progression of dental caries in children, characterized by transitions between distinct health states, may benefit the development of prevention and disease modeling frameworks. This systema...

Abstract Background Alcohol use disorder (AUD) represents a tremendous societal burden, yet few efficacious therapies are available and widely used. Pre-clinical and human observational data support fibroblast growth fac...

Shenfu Injection (SFI) is a standardized botanical drug derived from two Chinese medicinal herbs Panax ginseng C.A.Mey. and Aconitum carmichaelii Debeaux. SFI is historically used for “restoring yang and reversing coll...

Abstract BackgroundArtificial intelligence (AI) integrated with point-of-care imaging is a promising approach to expand access in settings with limited specialist availability. However, no systematic review h...

To systematically evaluate the measurement properties of current masticatory performance (MP) assessment methods in adult populations. A systematic search was performed in the PubMed, Cochrane Library, and EBSCOhost data...

BackgroundMetabolic syndrome (MetS) affects approximately 1.54 billion adults worldwide and is characterized by central obesity, insulin resistance, hypertension, and dyslipidemia. Chronic low-grade inflammation is cen...

ABSTRACT: Objectives: To evaluate and synthesise the current evidence on the efficacy of laser-activated irrigation in endodontics, with a focus on microbial reduction, postoperative outcomes, and its potential as an ad...

Abstract Background Cold water immersion (CWI) is a common method of post-exercise recovery, but the optimal protocols are not well understood. The lack of exercise-specific guidelines has caused confusion on how CWI sho...

Abstract Background The skin is the largest epithelial organ and a critical barrier. However, in preterm infants, particularly very low birth weight infants (VLBWI,

Background/objectivesAcupuncture is recommended for the treatment of cancer-related fatigue (CRF), but the strength of evidence remains limited. This study aims to comprehensively update the evaluation of the effectivene...

Abstract Background The holistic health of children, encompassing physical, psychological, and social domains, plays a crucial role in long-term societal development. However, evidence suggests that many young people eng...

Abstract Background Diabetic Foot Ulcers (DFUs) represent a global healthcare challenge, imposing substantial socioeconomic burdens due to their increasing incidence and associated mortality. This study evaluates the eff...

ObjectivesTo conduct a scoping review mapping the extent, nature, and consistency of available evidence regarding the effects of sodium–glucose cotransporter-2 (SGLT2) inhibitors on kidney function, proteinuria, kidney...

Despite decades of global attention, work-related musculoskeletal disorders (MSD) remain a significant challenge, with substantial personal and societal costs (1). The lack of progress in addressing this prevalent proble...

BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...

Abstract Background Coffee is among the most widely consumed beverages globally, yet evidence specifically examining its association with heart failure (HF) risk remains limited. The only dedicated meta-analysis on this ...

Abstract Human papillomavirus (HPV) vaccination is a safe and cost-effective strategy for preventing cervical cancer, yet uptake remains low worldwide, particularly in low- and middle-income countries (LMICs). Numerous i...

BackgroundAn interdental brush (IDB) is an adjunctive oral-hygiene tool designed to clean interproximal spaces and remove dental plaque. This study systematically evaluated its effectiveness for improving oral hygiene an...

Objective: To present the first systematic review on the empirical evidence for variations in intraindividual pain intensity in patients with long-term pain conditions. Methods: The search was conducted on Medline and in...