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Abstract Background Alcohol use disorder (AUD) represents a tremendous societal burden, yet few efficacious therapies are available and widely used. Pre-clinical and human observational data support fibroblast growth fac...

Abstract Respiratory syncytial virus (RSV) is the leading global cause of serious respiratory disease in infants and an important respiratory pathogen in older adults. The RSV prefusion F protein (preF) is a major target...

Common variable immunodeficiency (CVID) is a group of heterogeneous disorders with common denominators of impaired antibody production and function and recurrent infections. Currently, prognostic biomarkers for CVID are ...

Background. Pediatric abdominal pain accounts for more than 1 million emergency department (ED) visits annually, and appendicitis is the most common surgical emergency. Guidelines recommend ultrasound as the initial imag...

BackgroundNFKB1 encodes for the p105/p50 nuclear factor-kappa-B (NF-kB1) transcription factors. Heterozygous mutations in NFKB1 may lead to NF-kB1 insufficiency, which may result in a multiorgan disease. Here, we aimed t...

Cognitive judgement bias (CJB) tests have become indispensable for assessing animal emotions. However, the methodology can vary profoundly. In mice, for example, approaches based on vision, spatial orientation and olfact...

Abstract Background Adrenaline is an emergency medication used in critical situations. However data on its early adverse events after intravenous injection are limited. Therefore, the goal of this study is to describe th...

BackgroundThe integration of artificial intelligence (AI) into emergency medicine holds promise for enhancing early diagnosis and clinical decision-making. Traditional diagnostic approaches often rely on physician judgme...

Abstract Background Therapeutic Communities (TCs) are long-term residential treatment settings for individuals with substance use disorders, who often present with neuropsychological impairments. These impairments may in...

Abstract Background Scabies incidence has rapidly increased in the Netherlands, particularly among higher education students. We hypothesized that effective control in this group is hindered by poor contact notification ...

BackgroundNFKB1 encodes the p105/p50 nuclear factor-kappa-B (NF-κB1) transcription factor. Heterozygous mutations in NFKB1 are associated with NFKB1-related disease, including granulomatous-lymphocytic interstitial lung...

Abstract Background Migraine burden is over twice as high among females than males. Although sex differences are recognized in migraine, robust sex-specific guidance for management remains limited. Objective To systemati...

Abstract Background Despite concerted global efforts, urogenital schistosomiasis remains an important public health challenge in sub-Saharan Africa. Understanding the local dynamics of this disease is crucial for effecti...

Digitaalsete vahenditega toetatud õpikeskkonnad pakuvad uusi võimalusi, kuidas kohandada õppimist, kuid eeldavad õpetajatelt mitmemõõtmelist pädevust, mis seob digioskused, pedagoogilised teadmised ja õppijate mi...

Abstract DNA methylation quantification in age-prediction models relies on only a few techniques with inherent limitations and biases, reducing the accuracy and reproducibility. We developed a new droplet digital PCR ass...

Background Tubeless insulin pumps, introduced in France in 2016, have been associated with higher user satisfaction than tubed pumps, primarily due to reduced interference with daily tasks. Whether this translates to gre...