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Over the past few decades, the pharmaceutical sector has witnessed the occurrence of a particular type of agreement used to settle patent disputes between originator and generic drug manufacturers: so-called reverse paym...

Background China seems to have entered into a new global leadership phase of economic diplomacy where its actors increasingly resort to new resources, tools and strategies serving well-defined national interests, such as...

Abstract Background Undernutrition remains a major public health concern among HIV-positive children. Despite advancements in antiretroviral therapy (ART) effectiveness in managing HIV, these children still face nutritio...

BackgroundThe 2025 United States government shutdown (October 1–November 12) resulted in historic disruptions to benefit distribution for the Supplemental Nutrition Assistance Program (SNAP). The purpose of this study ...

Abstract Background Timely diagnosis and therapeutic management of rare diseases (RDs) are greatly hampered by limited clinical information and a lack of reliable epidemiological data. RDs constitute a heterogeneous grou...

INTRODUCTION. The interpretation of visual and linguistic codes, legal and ethical security, the application of technologies such as artificial intelligence, and the need to develop regulatory standards to prevent confli...

Abstract Background The skin is the largest epithelial organ and a critical barrier. However, in preterm infants, particularly very low birth weight infants (VLBWI,

IntroductionGender equity remains a central issue in contemporary research and public policy, shaped by structural, cultural, and institutional inequalities. Despite increased academic attention, the field continues to e...

Abstract Objective Financial toxicity, characterized by the financial burden and psychological distress associated with cancer treatment, has become a critical issue impacting patient outcomes and quality of life. This s...

Artificial intelligence-supported online assessment and evaluation (AI-SOAE) systems have the potential to transform assessment and evaluation processes in higher education; however, there is a need for a comprehensive e...

RationaleActivated PI3K delta syndrome (APDS) is a rare primary immunodeficiency disease (PID) characterized in 2013. Caregivers of children with APDS juggle management of complex medical needs with family and work respo...

BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...

Abstract Background Maxillary transverse deficiency is one of the most common issues encountered in orthodontic practice. Ideally, intervention should take place before the midpalatal suture has completely ossified, in o...

Abstract Background Children with congenital and acquired heart disease (CAHD) are at high risk for venous thromboembolism (VTE). Traditional anticoagulants such as vitamin K antagonists (VKAs) and low-molecular-weight h...

Background: Holistic nursing care integrates the physical, social, spiritual and psychological dimensions of well-being. Sexual and gender minority (SGM) groups experience healthcare disparities because of non-inclusive...

Abstract Objective This study aimed to explore the facilitative and obstructive factors of self-management in patients undergoing maintenance hemodialysis to provide a reference for improving patient self-management in C...

Pigment anomalies such as leucism and albinism are rare in wild mammals, often linked to genetic or developmental factors and sometimes carry ecological consequences. Here, we report the first record of leucism in the Ro...

The foundation of transitional justice in the history of the Democratic Republic of the Congo (DRC) dates back to the Conférence Nationale Souveraine (CNS) held from August 7, 1991 to December 1992. The CNS lasted for 1...

This study investigates how algorithmic infrastructures on Chinese social media govern visibility not through post-hoc deletion but through pre-emptive design. Focusing on Xiaohongshu during the 2025 China—U.S. trade c...

Background The general practitioners’ (GP) workforce is in crisis, with 22% of GPs feeling so stressed by the pressures of general practice they cannot cope. Patient death is the greatest stressor in medical practice a...

Despite decades of global attention, work-related musculoskeletal disorders (MSD) remain a significant challenge, with substantial personal and societal costs (1). The lack of progress in addressing this prevalent proble...

Purpose: This paper aims to examine the green management practices adopted by small and medium enterprises (SMEs) in The Gambia and to analyze how these practices contribute to competitive advantage within a resource-con...

Financial accountability in Indonesian BLU polytechnics — institutions managing State Budget allocations under Public Service Agency status — remains a persistent governance challenge. Recurring financial irregularit...

BackgroundOpioid overdose remains a leading cause of preventable death in the United States. Existing approaches to identify individuals at elevated risk rely on imprecise rule-based criteria that misclassify patients’...