NODOVOX | Discovery

Phytochemical-mediated green synthesis of selenium nanoparticles using Catharanthus roseus and their physicochemical characterization, biological evaluation, and molecular docking analysis

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Phytochemical-mediated green synthesis of selenium nanoparticles using Catharanthus roseus and their physicochemical characterization, biological evaluation, and molecular docking analysis

Abeer F. Desouky et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract This study reports the green biosynthesis of bioactive selenium nanoparticles using Catharanthus roseus extract as a reducing and stabilizing agent. Liquid chromatography–electrospray ionization tandem mass sp...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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Integrated analysis of Morusin inhibiting esophageal cancer via network pharmacology molecular dynamics simulation and in vitro validation

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Integrated analysis of Morusin inhibiting esophageal cancer via network pharmacology molecular dynamics simulation and in vitro validation

Miyuan Yang et al · Springer · 2026 · ISSN 2730-6011

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng

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Discovering TEAD4 modulators for hepatocellular carcinoma: a GAN-enabled generative modelling framework

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Discovering TEAD4 modulators for hepatocellular carcinoma: a GAN-enabled generative modelling framework

Varshni Premnath et al · Frontiers Media S.A · 2026 · ISSN 2673-7647

IntroductionLiver diseases continue to impose a major global health burden, and therapeutic progress is constrained by the limited availability of validated small-molecule modulators. TEAD4, a central Hippo-YAP effector,...

LCC TENDOkNvbXB1dGVyIGFwcGxpY2F0aW9ucyB0byBtZWRpY2luZS4gTWVkaWNhbCBpbmZvcm1hdGljcw~~Idioma eng

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Luteolin induces mitochondria-dependent apoptosis and senescence in myelodysplastic syndrome cells by targeting the Akt signaling pathway

Tesis

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Luteolin induces mitochondria-dependent apoptosis and senescence in myelodysplastic syndrome cells by targeting the Akt signaling pathway

LI Jiarun et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

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Protein order and disorder: A quantitative in silico analysis

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Protein order and disorder: A quantitative in silico analysis

de Brevern Alexandre G · EDP Sciences · 2026 · ISSN 2100-014X

Proteins are fundamental biological macromolecules responsible for a wide range of cellular functions. Traditionally, a central paradigm linked the amino acid sequence to a unique, ordered three-dimensional structure tha...

LCC TENDOlBoeXNpY3M~Idioma eng

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The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface

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The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface

Verena Höffken et al · Life Science Alliance LLC · 2026 · ISSN 2575-1077

Based on a combination of in silico and cell biological analyses, this study suggests that the APOL1 variant p.N264K (M1) may prevent G2-mediated kidney toxicity by physically blocking ion flux. The APOL1 gene variants G...

LCC LCC:Medicine; LCC:Biology (General)Idioma eng

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