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Glioblastoma stem cells (GSCs) and residual tumor cells - which resist conventional therapies, drive disease recurrence, and contribute to the formation of an immunosuppressive tumor-immune microenvironment (TIME) - repr...

ABSTRACT Objective: To present the results of the surgical treatment of adolescent idiopathic scoliosis (AIS) using a less invasive technique. Methods: Ten patients diagnosed with AIS underwent surgical treatment using a...

Abstract Objective To outline the demographic and clinical characteristics of patients with deep intestinal endometriosis submitted to surgical treatment at a tertiary referral center with a multidisciplinary team, and...

Background: Humeral shaft fractures account for approximately 3 % of all fractures and exhibit a bimodal age distribution. Dynamic compression plating (DCP) and locked compression plating (LCP) are two principal methods...

Abstract Background Lung cancer surgery in low- and middle-income countries (LMICs) is frequently challenged by late-stage presentation, high comorbidity burden, and limited healthcare resources. Although video-assisted ...

Background: Total Knee Arthroplasty (TKA) is an effective treatment for osteoarthritis of the knee. The purpose of this study is to evaluate patient reported outcomes in terms of overall satisfaction, improvement in pain...

ObjectiveCurrent treatment strategies for acute lower extremity deep vein thrombosis (DVT) have shifted from merely preventing pulmonary embolism to actively removing thrombus and preserving valve function. However, ther...

IntroductionGouty tophi are chronic inflammatory nodules resulting from monosodium urate (MSU) crystal deposition, often leading to joint deformity, skin ulceration, and functional impairment. Surgical management remains...

ABSTRACT Background Myxomatous mitral valve disease (MMVD) can cause pulmonary hypertension (PH). Mitral valve repair (MVR) has been described as a surgical treatment option for MMVD, but the benefit of MVR when PH is pr...

Abstract Background Colovesical fistula (CVF) is a rare condition characterized by the passage of air and/or feces in the urine, but there is still no consensus on the evaluation and treatment of this condition. This stu...

Introduction Osteoarthritis is a frequent degenerative joint disease, affecting older individuals in particular. When non-surgical treatment options are no longer effective or warranted, surgical options include single c...

In recent years, considerable progress has been made in frontline therapy for elderly/physically unfit patients with CLL. The combination of obinutuzumab and chlorambucil (O-Clb) has been shown to prolong progression fre...

ABSTRACT Objective This study introduces a modified minimally invasive transforaminal lumbar interbody fusion (MIS‐TLIF) technique to address the limitations of conventional MIS‐TLIF, including soft tissue injury, ex...

ABSTRACT The aim of this case study was to apply a robust fixation method using the plate rod technique, which combines intramedullary pins with bone plates to provide rigid stabilization. Although commonly used in mamma...

Background: Lymphovenous anastomosis (LVA) has recently emerged as a potential method for the symptomatic management of Alzheimer’s disease (AD). Building on this, we conceptualize the "dynamic neck LVA" (Dn-LVA) to il...

ObjectiveThis study aimed to compare the safety and feasibility of transumbilical laparoscopic-assisted appendectomy (TULAA) vs. three-port laparoscopic appendectomy (TPLA) for the treatment of acute appendicitis in chil...

Background: Fractures of the proximal third of the tibia commonly result from high-velocity trauma, particularly road traffic accidents, and are often associated with significant soft-tissue injury. Their management rema...

Two adult domestic shorthair cats were evaluated for progressive neurologic deficits caused by spinal cord compression secondary to vertebral osteosarcoma, giant-cell subtype. Feline giant cell osteosarcoma represents a ...

Abstract Background Suprasellar meningiomas are classically removed through several different surgical transcranial approaches, including the pterional transsylvian route. Recently, the indications for the transsphenoida...

Abstract Background Retroperitoneal lymphatic malformations (LMs) are rare, and their deep location adjacent to critical structures renders treatment particularly challenging. This retrospective study aims to investigate...

INTRODUCTION: Intussusception is one of the most common causes of acute abdominal pain in childhood, and early diagnosis with appropriate treatment can reduce the need for surgery. This study aimed to evaluate the clinic...

BackgroundRobot-assisted simple prostatectomy (RASP) and laser enucleation of the prostate (LEP) are established surgical options for the treatment of large-volume benign prostatic hyperplasia (BPH); however, consensus r...

BackgroundTherapeutic vulnerability in gastric cancer is profoundly influenced by the tumor microenvironment (TME), yet reliable and clinically actionable preoperative indicators remain insufficient.MethodsWe developed a...

Abstract Background Ebstein anomaly is a rare congenital malformation of the tricuspid valve. Although robotic-assisted minimally invasive repair has shown promising results, its high cost limits accessibility in develop...