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Objective Gestational diabetes mellitus (GDM) refers to glucose intolerance, insulin sensitivity, and beta islet cell dysfunction during pregnancy. GDM pathogenesis is associated with hypertension, impaired placental and...

HOPX (homeodomain-only protein), a member of the homeodomain family, is involved in various developmental processes and immune regulation. This study highlights HOPX expression in human placenta and its potential role in...

Introduction: The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipoc...

ABSTRACT This study was conducted to follow up the histopathological changes in kidney of mice experimentally infected with tissue cysts of Toxoplasma gondii, isolated from placenta of women, ewes, and does naturally inf...

The mechanisms by which probiotic bacteria exert their effects on the immune system are not completely understood, but the epithelium may be a crucial player in the orchestration of the effects induced. In a previous wor...

Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and develo...

Community-acquired pneumonia (CAP) remains a major global public health challenge with substantial morbidity and mortality. Although preclinical studies suggest that Maxing Huoqiao (MXHQ) granule may have therapeutic pot...

Gestational trophoblastic disease (GTD) includes both neoplastic and nonneoplastic disorders arising from placental trophoblastic tissue. Among tumor-like conditions, exaggerated placental site reaction (EPSR) is a rare ...

Abstract Background Neuroinflammation following intracerebral hemorrhage (ICH) is a critical contributor to secondary brain injury. Lactylation modification, a novel epigenetic regulatory mechanism, may participate in pa...

Abstract Intervertebral disc (IVD) degenerative disease is a prevalent and debilitating spinal disease. Current treatments only focus on symptomatic relief but fail to halt disease progression or restore the native biome...

Tumor metastasis is the leading cause of mortality in patients with malignant cancers, and the establishment of the pre-metastatic niche (PMN) is recognized as a pivotal step in this process. With growing insight into th...

In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-se...

Metabolic dysfunction-associated steatohepatitis (MASH) is a major challenge in hepatology. Despite considerable progress in our understanding of MASH, the particular mechanisms underlying disease development and the var...

Infection by Brucella species in pregnant animals and humans is associated with an increased risk of abortion, preterm birth, and transmission of the infection to the offspring. The pathogen has a marked tropism for the ...

The development of dye-sensitized solar cells requires an in-depth understanding of the interfacial charge-transfer dynamics that take place between dye sensitizers and semiconductors. Here, we describe a prototype syste...

The main purpose of this work was to show that by using low‐pressure plasma it is possible to obtain platinum nanoparticles with uniform size and shape and then apply these nanoparticles in order to evaluate the proces...

Abstract Recent studies have demonstrated that exosome therapy can promote the recovery of ovaries in premature ovarian failure (POF) models, which may aid in fertility restoration. This study aimed to investigate the th...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

BackgroundFibromyalgia affects 2%–8% of the global population with suboptimal treatment outcomes. Emerging evidence suggests histamine intolerance, mediated by diamine oxidase (DAO) deficiency, may contribute to fibrom...

The enzyme heme oxygenase-1 (HO-1) is pivotal in reproductive processes, particularly in placental and vascular development. This study investigated the role of HO-1 and its byproduct, carbon monoxide (CO), in trophoblas...

Abstract Objective High-altitude chronic hypoxia can alter the immune status, yet the immune regulatory characteristics of various vaccine adjuvants in this environment remain to be fully elucidated. Accordingly, emph...

Abstract Background Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains poorly characterized at the post-transcriptional regulation level. While alternative splicing (AS) perturbations drive...

Abstract Introduction Bladder cancer (BLCA) is a malignant tumour that occurs on the mucosa of the bladder. It accounts for the first place in the incidence of genitourinary tumours in China. BLCA is characterized by hig...

Con el objetivo de evaluar la degradación ruminal de Paspalum notatum (pasto horqueta) en rumen de bovinos en distintas épocas del año, en un campo del nordeste argentino se recolectaron muestras de dicha pastura a lo...