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Ophiocordyceps sinensis (formerly known as Cordyceps sinensis), commonly referred to as “dongchongxiacao” in Chinese, is a valuable traditional Chinese medicine whose bioactive small molecules form the essential mate...

Background: Plantar heel pain affects up to 10% of individuals and often limits activity. Corticosteroid injections provide short-term relief, though emerging evidence suggests that benefits may derive from mechanical st...

Shellfish peptides, recognized as a valuable source of marine bioactive compounds, have garnered increasing attention because of their diverse physiological functions and potential functional food, pharmaceutical, and co...

Abstract Advances in artificial intelligence (AI) and multi-omics integration are reshaping precision oncology by enabling deeper mechanistic understanding, improved characterization of tumor heterogeneity, and the accel...

Abstract Humoral factors regulating cardiac myocytes have not yet been fully elucidated. Using mass spectrometry, we analyzed peptides released from primary neonatal rat cardiac fibroblasts to identify a 24-amino-acid pe...

Animal-bite and scratch visits to the emergency department (ED) often require time-sensitive decisions on rabies post-exposure prophylaxis (PEP) alongside tetanus prevention. In China, recent national standards and local...

Peptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often in...

TRPM2 is a calcium-permeable cation channel that functions as an oxidative stress sensor and plays a key role in various pathologies, particularly ischemic stroke. The activation of hsTRPM2 requires cooperative engagemen...

Abstract Antimicrobial peptides (AMPs) are a diverse class of short peptides with therapeutic potential as antimicrobial agents and immune regulators. Many anurans (frogs and toads) produce diverse sets of AMPs via speci...

This study aimed to evaluate the impact of fruit maturity stage, storage container type, and storage duration on the content of active compounds and vitamins in hot pepper fruits (Capsicum frutescens L.), as these are im...

The relentless pursuit of athletic excellence is shadowed by the equally persistent evolution of performance-enhancing drugs (PEDs). In recent years, the antidoping landscape has been profoundly shaped by the rise of two...

Antimicrobial resistance represents a major global health challenge, particularly in the context of multidrug-resistant bacteria. Although conventional antibiotics and antimicrobial peptides (AMPs) both exert selective p...

There is a wealth of structural data on peptides that bind potential drug targets, serving as rich inspiration for designing small molecule inhibitors which can recapitulate key binding interactions while improving pharm...

Abstract Accumulation of amyloid beta 1–42 (Aβ42) peptide in the extracellular space in the brain is a major observation in Alzheimer’s Disease (AD)-related pathology. Astrocytes are known to play pivotal role in cl...

Surface adhesion is critical to the survival of pathogenic bacteria both in natural niches and during infections, often via forming matrix-embedded communities called biofilms. Vibrio cholerae, the causal agent of pandem...

Rational protein design has successfully enhanced the mechanical stability of biomaterials by optimizing the internal topology of force-bearing domains. However, current design strategies predominantly focus on isolated ...

X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors. Without definitive therapy, SCID-X1 i...

Abstract Background After resection surgery, recurrence occurs in more than 30% of colorectal cancer (CRC) patients. Previous studies have highlighted the role of the gut microbiota in CRC initiation and progression; how...

Dimitra Peppa,1–3 Aljawharah Alrubayyi,1,4 Sanjay Bhagani1,5 1Division of Infection and Immunity, University College London, London, UK; 2Mortimer Market Centre, Department of HIV, CNWL NHS Trust, London, UK; 3...

ABSTRACT Selective recognition of cancer‐associated proteins (CAPs) by antibodies, followed by their delivery into the intracellular organelle, the lysosome, results in targeted degradation of CAPs and suppresses the g...

IntroductionAntimicrobial resistance (AMR) is rising globally, particularly among the clinically important ESKAPE pathogens, a group of bacteria responsible for a large number of hospital-acquired infections and known fo...

Diabetes mellitus emanates from a dysfunctional metabolic process and it affects human population globally, and causes a decline in the quality of life and increase in mortality rate due to its complications and adverse ...

Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer; however, first-line therapeutic agents show limited efficacy in patients with advanced disease. Bioactive peptides have emerged as p...

IntroductionThe secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This “cell-free” strategy offers a promising alternative to stem ...