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Materias / palabras clave: Rockefeller Foundation.; Yellow fever; History.; Medicine, Preventive; Mexico.; Public health; Medicina preventiva.; Salud pública.; México.

Materias / palabras clave: Rockefeller, Nelson A.; United States.; History.; World War, 1939-1945; Diplomatic history.; Guerra mundial, 1939-1945; Historia diplomática.; Latin America; Foreign relations; América Latina; Relaciones internacionale...

Materias / palabras clave: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Resumo: O presente artigo analisa a recepção do Laboratório da Fundação Rockefeller na Bahia, entre 1928 e 1930, como propulsor de interações entre agentes de saúde e agentes de construção de conhecimento cient...

Fil: Ramacciotti, Karina Inés. Universidad Nacional de Quilmes; Argentina. Fil: Ramacciotti, Karina Inés. Universidad de Buenos Aires. Facultada de Filosofía y Letras. Instituto Interdisciplinario de Estudios de Géne...

Fil: Myers, Jorge. Universidad de Buenos Aires. Facultad de Filosofía y Letras.; Argentina.

Materias / palabras clave: OpenAIRE; Research Graph; publications; 03 medical and health sciences; R; Medicine; 0601 history and archaeology; 06 humanities and the arts; Public aspects of medicine; RA1-1270; 0305 other medical science; Crossref; i...

A 5-year-old female presented at age 2 with recurrent respiratory and ear infections, aphthous ulcers, and severe neutropenia (absolute neutrophil count [ANC] = 400 cells/mcl). Immunological testing at age 4 showed neutr...

HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...

Serum sickness is an immune complex-mediated hypersensitivity reaction, classically manifested by the triad of fever, rash, and arthralgias. It results from the formation and deposition of antigen–antibody complexes, l...

IntroductionHyperuricemia, pulmonary hypertension, renal failure, alkalosis (HUPRA) syndrome is a mitochondrial disease caused by mutations in SARS2 (seryl-tRNA synthetase 2), which plays a role in protein synthesis. Lim...

IntroductionThe T cell receptor excision circle (TREC) assay is an effective neonatal screening tool for severe combined immunodeficiency (SCID), enabling early diagnosis and timely intervention. While genetic analysis o...

A 12-day-old full-term (FT) male presented with one day of diarrhea and respiratory distress. The exam was notable for hypothermia, tachycardia, and hypoxemia. Initial bloodwork showed leukopenia (3,400 cells/uL, absolut...

Hoyeraal-Hreidarsson syndrome (HHS) represents the most severe form of dyskeratosis congenita (DC), a telomere biology disorder caused by pathogenic variants in genes involved in telomere maintenance. DKC1 encodes dysker...

CD40L-deficient X-linked hyper IgM (XHIGM) syndrome is characterized by defective B cell class switching, deficiency of immunoglobulins G, A, and E, plus other immune abnormalities due to disrupted CD40L–CD40 interacti...

IntroductionKabuki syndrome (KS) is a rare, complex, multisystem, neurodevelopmental congenital disorder with characteristic phenotypic anomalies and pathogenic genetic variants of the KMT2D or KDM6A genes. KS is highly ...

BackgroundIL-2Rβ (CD122) is essential for IL-2 and IL-15 signaling and for natural killer (NK) and T cell homeostasis. We and others have recently described biallelic loss-of-function IL2RB variants, primarily affecting...

We present the case of a 17-year-old male with a long-standing history of recurrent and persistent cutaneous abscesses beginning at 6 years of age. Lesions were widespread, affecting the scalp, trunk, buttocks, and extre...

Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...

Deficiency in ELF4, X-linked (DEX) is a monogenic autoinflammatory disorder caused by loss-of-function (LOF) mutations in the ETS transcription factor ELF4. This rare disorder primarily affects young, male patients due t...

Autosomal-dominant hyper-IgE syndrome (AD-HIES) is characterized by chronic mucocutaneous candidiasis, recurrent sinopulmonary pneumonias, noninflammatory atopic dermatitis, extremely high levels of serum IgE, and non-im...

IntroductionPediatric hemophagocytic lymphohistiocytosis (pHLH) is a life-threatening condition characterized by aberrant immunopathology and systemic manifestations. The HLH-2004 protocol prioritizes urgent immunosuppre...

The United States Immunodeficiency Network (USIDNET) is a registry that collects de-identified patient data from hospitals across the country to study rare immune conditions, including inborn errors of immunity (IEI). Th...

IntroductionIndividuals with inborn errors of immunity (IEI) are increasingly reaching reproductive age, yet guidance on fertility preservation, genetic counseling, medication adjustments in pregnancy and breastfeeding, ...