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BackgroundAs populations age rapidly, community-based care is crucial to support aging-in-place. Yet, few models successfully integrate health promotion, social engagement and care coordination at scale. Singapore’s Ac...

Microplastics in agricultural soils may act as sorptive agents for organic contaminants. This study investigated the effects of soil aging of linear low-density polyethylene (LLDPE) microplastics on the sorption and deso...

IntroductionWith the intensification of global population aging, mental health problems among older adults have become increasingly prominent. As an important innovative approach in smart eldercare, artificial intelligen...

Aging is characterized by measurable reductions in tissue repair, immune balance, and metabolic regulation. Increasing evidence suggests that these changes may arise, in part, from an insufficiency or altered quality of ...

Li Tao,1,2,* Meiling Tai,3,* Zhuang Zhou,3 Zhenwen Chen,1 Rongjinlei Zhang,1 Yuanlong Ge,1 Zhenyu Ju1 1Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative...

This study investigates whether remodeling/enhancing the two vital proteins—hemoglobin and B3p—in erythrocytes with artificial interference can rejuvenate aged and damaged erythrocytes. Using Raman spectroscopy and S...

Aging is an irreversible and natural phenomenon. At the biological level, aging is caused by various molecular and cellular damages over time. Evidence of Anti-aging were observed in Yeast, Worms and Mice with metformin....

Abstract Background Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that is linked to cardiovascular, metabolic, and neurocognitive complications. However, its diagnosis relies on polysomnograp...

Abstract Astrocytes play key roles in maintaining brain homeostasis, metabolism, and neurovascular integrity, yet their diversity and age-related modulation remain insufficiently understood, particularly across primate l...

Abstract Polygonati Rhizoma has been reported to exhibit the ability to retard skin aging. However, the precise molecular mechanisms underlying remain largely elusive. In this study, we screened 9 active compounds in Pol...

Abstract Background Inpatient care improves and maintains population health but requires a clear understanding of the drivers of inpatient care utilization. In Germany, inpatient cases increased from 16.5 to 19.4 million...

INTRODUCTION: In vitro studies indicate that UV radiation causes photoaging in the skin through oxidative stress, collagen destruction, DNA damage, and chronic inflammation. These models play a critical role in the devel...

Abstract Objective Adverse childhood experiences (ACEs) have been increasingly recognized as potential predictors of cardiovascular disease (CVD), alongside established factors such as hypertension. This study examined t...

Abstract Background The rising global aging population has increased the prevalence of Alzheimer’s disease (AD), a condition with limited treatment options, making non-pharmacological interventions essential. While mob...

Abstract Background Mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but their clinical utility is limited by replicative senescence. Strategies that reverse aging while maintaining MSC identity...

BackgroundFrailty is a complex age-related clinical syndrome characterized by diminished physiological reserve and increased vulnerability to stressors. Cognitive function may be associated with frailty; however, evidenc...

ABSTRACT Background and Aim Evolutionary principles offer critical insights into pandemic dynamics but have been largely overlooked in contemporary responses to COVID‐19. Relaxed natural selection, increased global mob...

BackgroundCholangiocarcinoma (CCA) carries a dismal prognosis. Beyond clinical determinants, socioeconomic deprivation may also influence outcomes. Busan, a rapidly aging metropolitan area in Korea, provides a critical s...

Abstract Background Phosphatidylinositol transfer protein-1 (pitp-1) is involved in the phosphoinositide (PIP) cycle. The role of pitp-1 in promoting healthy longevity remains unknown. Our previous work showed that the P...

Abstract Background Thailand is undergoing a rapid demographic transition toward an aging society, with substantial challenges in ensuring health equity for older adults. While national-level health policies have expande...

IntroductionThis study aims to explore the relationship between residential context and health-related outcomes. It seeks to analyze the differences in sociodemographic profiles, health status, psychosocial well-being, a...

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Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...

Abstract Background New York City has recorded a historically low supply of housing affecting disproportionally low-resourced areas, including the Bronx. Affordable housing buildings are being built, however, little is k...