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Engineering of acidic pH-responsive anti-CD3 binding antibodies
Artículo
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Engineering of acidic pH-responsive anti-CD3 binding antibodies
Grégory La Sala et al · Taylor & Francis Group · 2026 · ISSN 1942-0862
The development of anti-CD3 antibody-based T cell engager therapeutics has improved the treatment of various malignancies, yet the challenge of achieving tumor-specific targeting while minimizing on-target off-tumor effe...
LCC LCC:Therapeutics. Pharmacology; LCC:Immunologic diseases. AllergyIdioma eng
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From biosimilars to breakthroughs: regulatory convergence toward evidence-efficient development of monoclonal antibodies
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From biosimilars to breakthroughs: regulatory convergence toward evidence-efficient development of monoclonal antibodies
Sarfaraz K. Niazi · Frontiers Media S.A · 2026 · ISSN 2674-0338
Regulatory science governing monoclonal antibody development has undergone a profound transformation over the past decade, shifting from empiricism-driven paradigms toward evidence-efficient, mechanism-based frameworks g...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Role of human leukocyte antigen alloantibodies and other immunological factors in pre-eclampsia
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Role of human leukocyte antigen alloantibodies and other immunological factors in pre-eclampsia
Tarun Kanti Sen et al · Manipal College of Medical Sciences, Pokhara · 2026 · ISSN 2467-9100
Background: The nature of rejection and fetal allograft survival following the host-versus-graft reactivity remains the subject of intense investigation. Pregnancy-induced hypertension, also known as pre-eclampsia, is a ...
LCC LCC:MedicineIdioma eng
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Serum epitope-specific anti-recoverin autoantibodies as biomarkers for lupus retinopathy
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Serum epitope-specific anti-recoverin autoantibodies as biomarkers for lupus retinopathy
Min Li et al · BMC · 2026 · ISSN 1478-6362
Abstract Background Lupus retinopathy (LR) is a sight-threatening complication of systemic lupus erythematosus (SLE), yet disease-specific serologic biomarkers are lacking. Previous studies have shown that anti-recoverin...
LCC LCC:Diseases of the musculoskeletal systemIdioma eng
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Detection and differentiation of pestivirus antibodies in sheep and suckler cow herds in Southern Germany
Artículo
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Detection and differentiation of pestivirus antibodies in sheep and suckler cow herds in Southern Germany
Judith Köster et al · BMC · 2026 · ISSN 1746-6148
Abstract Background Pestiviruses such as bovine viral diarrhea virus (BVDV) or the ovine border disease virus (BDV) are not strictly species-specific and can be transmitted between related animal species. Due to serologi...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE® 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study
Artículo
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Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE® 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study
Sofia Manousou et al · BMC · 2026 · ISSN 1756-6614
Abstract Background Graves’ hyperthyroidism is caused by stimulatory autoantibodies. Its diagnosis and monitoring are commonly based on measurement of thyrotropin receptor antibodies (TRAb) with unspecific immunoassays...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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Preexisting Antibodies to Virus-Like Particles (VLP) Derived from Helper-Dependent Adenovirus (HDAd) in Patients with Chronic Granulomatous Disease (CGD)
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Preexisting Antibodies to Virus-Like Particles (VLP) Derived from Helper-Dependent Adenovirus (HDAd) in Patients with Chronic Granulomatous Disease (CGD)
Claire Booth et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionChronic Granulomatous Disease (CGD) is an inborn error of immunity that can be treated by allogeneic hematopoietic stem cell transplantation (allo-HSCT) or experimental gene therapy. For viral vector-based in...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Validation of LILR antibody specificities and development of LILRA3-specific antibodies
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Validation of LILR antibody specificities and development of LILRA3-specific antibodies
Hiromu Tanimoto et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Leukocyte immunoglobulin (Ig)-like receptors (LILRs) constitute a family of 11 structurally related receptors predominantly expressed on immune cells. Despite their functional diversity, LILRs show a high degree of seque...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Adjuvant Strategies to Improve the Efficacy of Allergen Immunotherapy
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Adjuvant Strategies to Improve the Efficacy of Allergen Immunotherapy
Tabynov K et al · Dove Medical Press · 2026 · ISSN 1178-7031
Kaissar Tabynov,1,2,* Kairat Tabynov,2,3 Nikolai Petrovsky4,* 1International Center for Vaccinology, Kazakh National Agrarian Research University, Almaty, Kazakhstan; 2Preclinical Research Laboratory with...
LCC TENDOlBhdGhvbG9neQ~~; LCC:Therapeutics. PharmacologyIdioma eng
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An improved and high-throughput mpox virus microneutralization assay
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An improved and high-throughput mpox virus microneutralization assay
Danyang Li et al · Elsevier · 2026 · ISSN 2590-0536
Since the 2022 global mpox outbreak, the lack of specific antibodies for mpox virus (MPXV) detection has hindered precise immunoassays due to cross-reactivity among Orthopoxviruses (OPXVs). This study developed and chara...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~; LCC:Public aspects of medicineIdioma eng
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Determinants of success and failure of antibody-based strategies against respiratory viruses: insights from RSV and SARS-CoV-2
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Determinants of success and failure of antibody-based strategies against respiratory viruses: insights from RSV and SARS-CoV-2
Hai Guo et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) represent two extremes in the outcome of antibody−based interventions. The long−acting monoclonal antibody nirsev...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Evaluating southern pigtail macaques as an immunological model for human antibody responses
Artículo
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Evaluating southern pigtail macaques as an immunological model for human antibody responses
Veronica P. Zoest et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Antibody specificity is primarily derived from immunoglobulin (Ig) genes, which exhibit extensive genetic polymorphism both within and across species. Non-human primates (NHP) such as pigtail macaques are often ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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A Systems-Predicted Neutralizing Antibody Assay Identifies Compartment-Specific Features Correlating with Neutralization Breadth
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A Systems-Predicted Neutralizing Antibody Assay Identifies Compartment-Specific Features Correlating with Neutralization Breadth
Qixin Wang et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Quantifying neutralizing antibody levels across anatomical sites and understanding correlates of neutralization breadth is paramount for monoclonal antibody treatments and next-generation vaccination strategies. The syst...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Chronic hypoxia modulates vaccine adjuvant-induced specific immune responses: QML maintains stability while CpG significantly enhances
Tesis
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Chronic hypoxia modulates vaccine adjuvant-induced specific immune responses: QML maintains stability while CpG significantly enhances
ZHANG Miaomiao et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927
Abstract Objective High-altitude chronic hypoxia can alter the immune status, yet the immune regulatory characteristics of various vaccine adjuvants in this environment remain to be fully elucidated. Accordingly, emph...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma zho
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Efficacy of Revolution® Plus (selamectin plus sarolaner) for the prevention of transmission of Borrelia burgdorferi from infected Ixodes scapularis to cats
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Efficacy of Revolution® Plus (selamectin plus sarolaner) for the prevention of transmission of Borrelia burgdorferi from infected Ixodes scapularis to cats
Rachael Isdale et al · BMC · 2026 · ISSN 1756-3305
Abstract Background Borrelia burgdorferi and Anaplasma phagocytophilum are transmitted by Ixodes spp., with antibodies having been detected in cats in endemic areas. The combination of selamectin plus sarolaner (Revoluti...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Induction of Th2/Th17 responses: immunoprotective mechanisms of a hepatitis B core antigen-based multi-epitope vaccine against Klebsiella pneumoniae infection
Tesis
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Induction of Th2/Th17 responses: immunoprotective mechanisms of a hepatitis B core antigen-based multi-epitope vaccine against Klebsiella pneumoniae infection
LIU Dengjia et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927
Abstract Objective Klebsiella pneumoniae (Kp) is a clinically prevalent opportunistic pathogen, with escalating antimicrobial resistance posing substantial challenges. Current vaccine strategies are constrained by the...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma zho
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On the Use of Immunoglobulins for Pre-exposure Prophylaxis Against COVID-19 in Immunocompromised Patients
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On the Use of Immunoglobulins for Pre-exposure Prophylaxis Against COVID-19 in Immunocompromised Patients
Focosi D et al · Dove Medical Press · 2026 · ISSN 1178-6973
Daniele Focosi,1 Massimo Franchini,2 Arturo Casadevall3 1North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy; 2Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy; 3D...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Transposition of human oncology therapies to veterinary medicine: potential, challenges, and perspectives - a systematic review
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Transposition of human oncology therapies to veterinary medicine: potential, challenges, and perspectives - a systematic review
A.R. Fukushima et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2026 · ISSN 1678-4162
ABSTRACT The growing interest in transferring therapeutic advances from human to veterinary medicine has spurred research into monoclonal antibodies and advanced therapies for treating cancer in small animals. This syste...
LCC LCC:Animal cultureIdioma eng
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Understanding quantitative effects of anti-amyloid therapies on tau biomarkers and functional outcome. Insights from a comprehensive mechanistic quantitative systems pharmacology study
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Understanding quantitative effects of anti-amyloid therapies on tau biomarkers and functional outcome. Insights from a comprehensive mechanistic quantitative systems pharmacology study
Hugo Geerts et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
IntroductionAnti-amyloid antibodies have the potential to become the standard of care in Alzheimer’s Disease (AD) and large datasets from clinical trials allow the testing of predictive models on fluid biomarkers and f...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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hERG epitope mimic-decoy peptide corrects autoimmune-long QT syndrome in guinea pigs
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hERG epitope mimic-decoy peptide corrects autoimmune-long QT syndrome in guinea pigs
Michael Cupelli et al · Nature Portfolio · 2026 · ISSN 2730-664X
Abstract Background The most investigated form of autoimmune-long-QT-syndrome (LQTS) is caused by circulating anti-Ro/SSA(Sjögren’s syndrome-related antigen-A)-52kD antibodies, which cross-react with a specific sequen...
LCC LCC:MedicineIdioma eng
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