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Colorimetric assays offer a low-cost, accessible means of diagnostic testing but often suffer from subjective interpretation and variability caused by inconsistent imaging conditions. To address these challenges, we pres...

Abstract Background Tick-borne encephalitis virus (TBEV, Orthoflavivirus encephalitidis) is an arbovirus of the family Flaviviridae. It is the etiological agent of tick-borne encephalitis (TBE), a severe disease affectin...

Abstract Carbapenem-Resistant Acinetobacter baumannii (CRAB) poses a major public health threat due to its multidrug resistance and high mortality rates, necessitating rapid and accurate diagnostic tools for timely inter...

ABSTRACT The AAA+ ATPase valosin‐containing protein (VCP/p97) is a central regulator of protein homeostasis that is well characterized for its role in extracting and remodeling ubiquitinated substrates. Dysregulation o...

Nipah virus (NiV) is an emergent paramyxovirus that causes serious disease in humans and animals. Accurate quantification of neutralizing antibodies (nAB) against NiV is essential for vaccine development. The current sta...

Abstract Background Postoperative hemorrhage is one of the major complications of oral surgery. Conventional hemostatic methods, such as chair-side preparation of tranexamic acid (TXA)-soaked gauze or TXA mouthwash, ofte...

BackgroundNutritional programming by early-life nutrition exerts long-lasting effects on later-life health. In mammals, galactose, as a component of the milk sugar lactose, is consumed during lactation. Mouse studies sug...

Quantifying neutralizing antibody levels across anatomical sites and understanding correlates of neutralization breadth is paramount for monoclonal antibody treatments and next-generation vaccination strategies. The syst...

Abstract Background Viral infections of tomato plants present a significant threat to tomato production and yield. Mixed viral infections are common in field-grown tomatoes and are known to exacerbate disease symptoms; h...

Vaccination is widely used to control foot-and-mouth disease (FMD), necessitating robust approaches for evaluating vaccine potency to ensure a consistent supply of effective and safe vaccines. Traditional (in vivo) poten...

Abstract Research on garlic peel has identified a variety of bioactive compounds. This study highlights the significance of garlic peels and the marine fungal strain Paecilomycesmaximus PQ584815 in generating secondary m...

This commentary discusses the FDA’s drug approvals in 2025, with a particular focus on cancer therapies and the role of companion diagnostics (CDx). Cancer has emerged as the leading therapeutic area, accounting for 35...

Abstract Mutations in the CYFIP2 gene, particularly the R87C variant, are associated with severe epileptic encephalopathy, and present challenges for therapeutic development. This study utilized CRISPR/Cas9-edited human ...

Chlamydia psittaci is an obligate intracellular pathogen that poses a significant threat to both human and animal health. The current therapeutic strategies are limited by the emergence of potential drug resistance, unde...

Introduction and aims: Submucous cleft palate (SMCP) is a congenital craniofacial malformation. While TBX22 is a known pathogenic gene, the potential role of TBX15 in SMCP remains unclear. This study aimed to investigate...

Abstract Background Weyers acrofacial dysostosis (WAD) is a rare autosomal dominant ciliopathy caused by heterozygous pathogenic variants in the EVC2 gene. The classic phenotype includes short stature, dental anomalies, ...

Yellow fever (YF) is an epidemic disease caused by the yellow fever virus (YFV). Historically, it has caused several epidemics and continues to result in fatalities in South Sudan and other regions today. Due to its limi...

Abstract Background The efficacy of conventional αβ T cell-based immunotherapies is often limited by tumor immune evasion. γδ T cells can bypass these limitations through MHC-independent tumor recognition, but their ...

Abstract Purpose This study aims to investigate the mechanisms underlying ANXA1 and HMGB1-regulated autophagy in relation to growth and radioresistance in thyroid cancer cells. This exploration seeks to provide new theor...

Breast cancer is a major public health problem worldwide, leading to an urgent need for the development of new strategies to improve treatment efficacy and manage drug resistance. Doxorubicin is among the most commonly u...

IntroductionThe emergence of multidrug-resistant bacteria, particularly vancomycin-resistant enterococci (VRE), represents a critical threat to global public health. Therefore, the development of novel therapeutic strate...

Abstract Inorganic nanoparticles and bee venom are emerging anticancer agents with potential for tumor‑selective cytotoxicity and immune modulation. This study aimed to compare the anticancer activity of three inorgani...

BackgroundThe methylation status of cell-free DNA (cfDNA) shows promise for the clinical detection of cervical cancer and its precursors; however, its measurement in liquid biopsies is hindered by low cfDNA yields and te...

Abstract Ovarian cancer is one of the deadliest gynecological malignancies, mainly because of its silent development and the lack of effective conventional methods for diagnosis. Because of their extraordinary stabilit...