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ABSTRACT Bacillus subtilis CpgA (circularly permuted GTPase) is a ribosome assembly GTPase that has a secondary function as a metabolite proofreading enzyme. CpgA hydrolyzes 4-phosphoerythronate, a toxic metabolite produ...

ABSTRACT Zinc is a critical nutrient for all living organisms, including bacterial pathogens such as Corynebacterium diphtheriae, the causative agent of the severe human respiratory disease diphtheria. As such, zinc acqu...

ABSTRACT Mycobacterium smegmatis is nonpathogenic and fast-growing and is usually used as a model species of Mycobacterium. Studying basic metabolic mechanisms is crucial for accelerating mycobacterial research. Although...

ABSTRACT Streptococcus gallolyticus subsp. gallolyticus (SGG) is a bacterial pathogen implicated in bacteremia and endocarditis and is often associated with colon tumors in elderly individuals. The development of colorec...

ABSTRACT Cysteine proteases are hydrolases that share a common catalytic mechanism involving a nucleophilic cysteine thiol in a catalytic dyad or triad. Here, we review the current clans that make up the cysteine proteas...

ABSTRACT Cystic fibrosis (CF) and inflammatory bowel disease (IBD) represent distinct pathologies with unique genetic underpinnings; yet, they share remarkable similarities in gut microbiota dysbiosis and intestinal phys...

ABSTRACT The Com_YlbF domain-containing proteins inhibit sporulation, competition, and biofilm formation by affecting the activity of ribonuclease RNase-Y in Bacillus subtilis. Similar Com_YlbF proteins are found in Stap...

ABSTRACT Antimicrobial recalcitrance is a growing problem in today’s world. Not only are bacteria developing resistance at an alarming pace but the antibiotic discovery pipeline has gone dry, making antimicrobial stewa...

ABSTRACT Mycoplasma bovis is a highly infectious pathogenic microorganism that causes various clinical signs in cattle, including pneumonia, arthritis, and mastitis, often resulting in significant economic losses. The ad...

ABSTRACT Transcriptional regulation of metabolic operons is important for optimal carbohydrate use and for mitigating the accumulation of toxic intermediates. Here, we characterize SL1344_3500, encoding a putative IclR-l...

ABSTRACT Many bacteria produce flagella to swim and navigate through environments. Depending on the species, flagella are beneficial for other activities such as sensing surfaces to initiate biofilm development, secretio...

ABSTRACT Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that...

ABSTRACT Carbapenem resistance mediated by blaNDM-encoded metallo-beta-lactamases is often linked to ISAba125, an insertion sequence from the IS30 family, which is widely distributed among critical and high-priority bact...

ABSTRACT Increased susceptibility of elderly populations to infection is a major concern, as recently experienced by the coronavirus pandemic. Therefore, the treatment of infected elderly individuals is of immediate inte...

ABSTRACT Protein trafficking from the cytosol to specific sites of action is a fundamental process for bacterial survival and growth. In the monoderm gram-positive bacteria, this process involves traversing the cytoplasm...

ABSTRACT In Bacillota, quorum sensing can be mediated by RRNPP regulators that are activated by autoinducing peptides (AIPs). In this study, we derived a hidden Markov model profile from a 3D-informed alignment to establ...

ABSTRACT The bacterial flagellar filament acts as a propeller to drive most bacterial swimming. The filament is made of flagellin, known as FliC in Escherichia coli. FliC consists of four domains, the highly conserved co...

ABSTRACT Staphylococcus aureus is a common upper respiratory tract (URT) pathobiont with high carriage rates in the upper airway disease chronic rhinosinusitis (CRS). CRS is associated with increased prevalence and abund...

ABSTRACT Staphylococcus epidermidis, a ubiquitous inhabitant of human skin, has been known for decades for its capacity to form biofilm-associated infections on indwelling medical devices and has developed into a leading...

ABSTRACT Phthalates such as isophthalate, phthalate, and terephthalate are widespread environmental pollutants with significant health and ecological impacts. Comamonas testosteroni KF1 initiates isophthalate degradation...

Materias / palabras clave: microbial; community; model; mechanism

ABSTRACT Chlamydia trachomatis has a DNA topoisomerase I with a unique C-terminal domain (CTD) homologous to eukaryotic SWIB domains. This study focused on determining the function of the SWIB domain-containing TopA from...

ABSTRACT Bacteria can change morphology in response to stressors and changes in their environment, including infection of a host. We previously identified the bacterial species, Bordetella atropi, which uses nutrient-ind...