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Abstract Background Social isolation is a chronic psychological stressor with high translational relevance to depression in humans, particularly in the aftermath of the COVID-19 pandemic. However, few preclinical studies...

Mathematics and computer science play a pivotal role in modern biology. Dynamical models based on differential equations are particularly adapted to describe dynamic behaviors of many biological processes. However, tradi...

Abstract While binge drinking can significantly impact health negatively, it has become increasingly important to understand how sex differences contribute to this hazardous behavior, which may also serve as a risk facto...

Abstract Background Induced mutation through physical mutagens, such as gamma irradiation is an effective and complementary breeding tool to enhance crop improvement by increasing genetic variation and creating heritable...

Spinocerebellar ataxia type 8, a debilitating neurological disease with no effective treatment, is caused by a CAG•CTG expansion mutation. In SCA8 mice, metformin decreases repeat-associated non-AUG proteins and neuroi...

Subtle variations in nontraumatic early-life experience are associated with long-lasting trajectories in pups’ brain development and behavior. Understanding the mechanisms of individualization of emotional traits is cr...

Objective To investigate the influence of water on the monotonic and fatigue strength of a lithium disilicate glass-ceramic. Methods Ninety bar-shaped specimens (1.0 × 1.0 × 12.0 mm) were prepared from Advanced Lithium...

Abstract The social behaviors of microbes provide unique opportunities for testing social evolution theories. How can altruistic behaviors arise by natural selection is a central challenge in biology. Green-beard effect ...

Abstract Vertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for s...

ABSTRACT Biofilms play a crucial role in medical, industrial, and environmental microbiology, yet their structural complexity often makes them challenging to study in undergraduate teaching laboratories. We present a sim...

Objective: To determine the optimal dosing ratio of the herbal components within compound Hemerocallis citrina Baroni (H. citrina) extract concentrate (CHEC), evaluate its antidepressant effects in zebrafish and mouse mo...

Graph-based pangenome references often misrepresent Copy Number Variations (CNVs) and Variable Number Tandem Repeats (VNTRs) as alternative acyclic paths, which hinders downstream analyses, degrades alignment behavior, a...

Breast cancer is the most common type of cancer among women. Advances in medical technology have made early diagnosis possible. However, as with many other diseases, the diagnosis of breast cancer may be delayed due to h...

Abstract Introduction Perinatal mental health conditions are common yet frequently undertreated. Perinatal collaborative care models improve access to evidence‐based care but face implementation challenges related to w...

Abstract Tumor-associated macrophages can either promote or suppress cancer, but therapeutic targeting remains challenging because we lack a predictive framework for macrophage function. The prevailing M1/M2 paradigm ove...

Abstract The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that ...

Monascus pigments (MPs) are important azaphilone-type polyketide pigments, yet yield control, stability, and safety pose challenges. Using an epigenetic derepression strategy, we constructed an Ash2 deletion mutant in th...

Abstract Social decision-making involves intricate and dynamic interactions between brains, yet prior hyperscanning research primarily concentrated on investigating the overall patterns of interbrain synchrony (IBS), lea...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...

Abstract Melatonin plays a key role in circadian regulation, and its interaction with the gut microbiota may be critical for early-life development. Beyond its circadian function, melatonin dysregulation is implicated in...

Abstract Background Signal divergence and sensory preferences may cause reproductive isolation and eventually speciation between animal populations. These patterns are particularly well known in systems with acoustic or ...

Animal models of epilepsy are critical in drug development and therapeutic testing. However, dominant methods for evaluating epilepsy treatments face a tradeoff between higher throughput and etiological relevance. Screen...

Convergent extension (CE) is a fundamental morphogenetic process where oriented cell behaviors lead to polarized extension of diverse tissues. In vertebrates, regulation of CE requires both non-canonical Wnt, its co-rece...

Abstract Dynamic regulation of lipid membrane composition is fundamental to living cells; however, synthetic analogs capable of such regulation remain scarce. Here, we present an artificial cell platform in which riboswi...