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Spinocerebellar ataxia type 8, a debilitating neurological disease with no effective treatment, is caused by a CAG•CTG expansion mutation. In SCA8 mice, metformin decreases repeat-associated non-AUG proteins and neuroi...

Abstract Vertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for s...

Objective: To determine the optimal dosing ratio of the herbal components within compound Hemerocallis citrina Baroni (H. citrina) extract concentrate (CHEC), evaluate its antidepressant effects in zebrafish and mouse mo...

Abstract Introduction Perinatal mental health conditions are common yet frequently undertreated. Perinatal collaborative care models improve access to evidence‐based care but face implementation challenges related to w...

Abstract Social decision-making involves intricate and dynamic interactions between brains, yet prior hyperscanning research primarily concentrated on investigating the overall patterns of interbrain synchrony (IBS), lea...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...

Abstract Melatonin plays a key role in circadian regulation, and its interaction with the gut microbiota may be critical for early-life development. Beyond its circadian function, melatonin dysregulation is implicated in...

Abstract Background Signal divergence and sensory preferences may cause reproductive isolation and eventually speciation between animal populations. These patterns are particularly well known in systems with acoustic or ...

Animal models of epilepsy are critical in drug development and therapeutic testing. However, dominant methods for evaluating epilepsy treatments face a tradeoff between higher throughput and etiological relevance. Screen...

Abstract Background Social isolation is a chronic psychological stressor with high translational relevance to depression in humans, particularly in the aftermath of the COVID-19 pandemic. However, few preclinical studies...

A growing number of therapies are being developed to target the cell cycle machinery for the treatment of cancer and other human diseases. Consequently, a greater understanding of the factors regulating cell cycle progre...