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Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

IntroductionIntestinal ischemia-reperfusion (I/R) injury, a common and severe clinical condition with high morbidity and mortality, burdens healthcare systems. Our previous investigations established that a nano-delivery...

Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging and daunting task. The gene-annotation enrich...

Materias / palabras clave: bioinformatics, computational biology; Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Biology (General)

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

BackgroundThe dengue virus (DENV) can cause various clinical syndromes and organ damage, known as dengue fever, with the probability of developing severe dengue. However, the underlying mechanisms of host response agains...

Background: Liver hepatocellular carcinoma is a highly prevalent and lethal malignancy. The orphan cytokine receptor-like factor 3, although evolutionarily conserved and implicated in hematopoiesis and neuroprotection, r...

Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Abstract The role of Bisphenol A (BPA) in endometrial cancer (EC) remains uncertain. In this study, we integrated toxicological prediction, network toxicology, gene expression profiling, survival analysis, and molecular ...

Abstract Objective This study aimed to investigate the effect of miRNAs differentially expressed in serum exosomes on endothelial cells after myocardial infarction. Design & methods Specific pathogen-free male Sprague–...

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive malignancy with limited prognostic markers. Ubiquitin-specific peptidase 33 (USP33) has emerged as a potential modulator of ...

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and wide...

Materias / palabras clave: bioinformatics, computational biology; Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Biology (General)

Materias / palabras clave: bioinformatics, computational biology, systems biology, molecular biology, evolutionary biology; Science: Biology (General)

Materias / palabras clave: data visualisation, integrative bioinformatics, genomics, computational bioimaging; Medicine: Medicine (General): Computer applications to medicine. Medical informatics

Materias / palabras clave: genomics, proteomics, bioinformatics, epigenomics; Science: Biology (General); Medicine: Medicine (General): Computer applications to medicine. Medical informatics

Materias / palabras clave: bioinformatics, biotechnology, mathematical modelling, genomic variation, pathology, algorithms; Technology: Chemical technology: Biotechnology; Science: Biology (General)

Materias / palabras clave: bioinformatics, computational biology, genomics, gene expression, genetic and population analysis, data and text mining; Science: Biology (General): Genetics

Materias / palabras clave: genomics, proteomics, transcriptomics, epigenetics, bioinformatics; Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Biology (General): Genetics

Abstract Infectious disease diagnostics has been transformed by metagenomic next‐generation sequencing (mNGS), an unbiased approach that detects bacteria, viruses, fungi, and parasites in a single assay. By sequencing ...

BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alani...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

Background: Melanoma represents a highly aggressive and metastatic form of malignant skin cancer. that remains challenging to treat clinically. Tumor cells often reprogram nicotinamide adenine dinucleotide (NAD⁺) metab...

Abstract Objective: The present study has the following objectives: 1) identify differentially expressed proteins and pathways in blood samples of bipolar disorder (BD) compared to healthy controls (HC) by employing hig...