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Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging and daunting task. The gene-annotation enrich...

Materias / palabras clave: bioinformatics, computational biology; Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Biology (General)

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

BackgroundThe dengue virus (DENV) can cause various clinical syndromes and organ damage, known as dengue fever, with the probability of developing severe dengue. However, the underlying mechanisms of host response agains...

Background: Liver hepatocellular carcinoma is a highly prevalent and lethal malignancy. The orphan cytokine receptor-like factor 3, although evolutionarily conserved and implicated in hematopoiesis and neuroprotection, r...

Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Abstract Objective This study aimed to investigate the effect of miRNAs differentially expressed in serum exosomes on endothelial cells after myocardial infarction. Design & methods Specific pathogen-free male Sprague–...

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and wide...

Materias / palabras clave: bioinformatics, computational biology; Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Biology (General)

Materias / palabras clave: bioinformatics, computational biology, systems biology, molecular biology, evolutionary biology; Science: Biology (General)

Materias / palabras clave: data visualisation, integrative bioinformatics, genomics, computational bioimaging; Medicine: Medicine (General): Computer applications to medicine. Medical informatics

Materias / palabras clave: genomics, proteomics, bioinformatics, epigenomics; Science: Biology (General); Medicine: Medicine (General): Computer applications to medicine. Medical informatics

Materias / palabras clave: bioinformatics, biotechnology, mathematical modelling, genomic variation, pathology, algorithms; Technology: Chemical technology: Biotechnology; Science: Biology (General)

Materias / palabras clave: bioinformatics, computational biology, genomics, gene expression, genetic and population analysis, data and text mining; Science: Biology (General): Genetics

Materias / palabras clave: genomics, proteomics, transcriptomics, epigenetics, bioinformatics; Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Biology (General): Genetics

Abstract Infectious disease diagnostics has been transformed by metagenomic next‐generation sequencing (mNGS), an unbiased approach that detects bacteria, viruses, fungi, and parasites in a single assay. By sequencing ...

BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alani...

Objective: To investigate the role of integrin beta-1 (Itgb1) in radiation-induced tissue injury and elucidate its underlying molecular mechanisms. Methods: Differentially expressed genes associated with radiation injury...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

Abstract Objective: The present study has the following objectives: 1) identify differentially expressed proteins and pathways in blood samples of bipolar disorder (BD) compared to healthy controls (HC) by employing hig...

The incidence of lung cancer in Indonesia by 2020 has reached 34.783 cases. Melinjo contains ursolic acid and polydatin, which can suppress cell proliferation and induce cell apoptosis, respectively. This study aims to d...

Abstract Background The role of the gastric microbiome in development or persistence of equine glandular gastric disease (EGGD) remains to be investigated. Hypothesis/Objectives The objective was to characterize the glan...

MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression at post-transcriptional level and play essential roles in biological processes such as development. MiRNAs silence target mRNAs ...