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Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

Background: Conventional electrocardiography (ECG) analysis faces a persistent dichotomy: Expert-defined features provide interpretability but are limited in capturing latent high-dimensional patterns, whereas deep learn...

Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive hepatobiliary malignancy characterized by a complex pathogenesis and poor prognosis. Telomere dysfunction and cellular senescence are involved in the pat...

This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organism...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...

Abstract Background Genetic aberrations are among the critical driving factors of lung cancer. Importantly, the impact of genetic variations on proteomic dysregulations with the goal of characterizing potential diagnosti...

BackgroundFibroblast growth factor receptor (FGFR) inhibitors (FGFRis) benefit selected cholangiocarcinoma (CHOL) patients, yet responses remain heterogeneous and are not fully explained by canonical FGFR alterations. Cl...

Asparagine-linked glycosylation 13 homolog (ALG13) encodes a nonredundant, highly conserved, X-linked uridine diphosphate (UDP)-N-acetylglucosaminyltransferase required for the synthesis of lipid linked oligosaccharide p...

Abstract Diminished ovarian reserve (DOR) lacks strong plasma biomarkers, and recent studies have implicated lipid remodeling in its pathophysiology. In our previous study, we noted elevated circulating levels of semapho...

ABSTRACT Background and Objectives Systemic inflammation indices derived from complete blood counts (CBC) are accessible markers of inflammatory burden, but their relationship with circulating cytokines in psoriasis rema...

Category: Ankle, Basic Sciences/Biologics Keywords: Achilles Tendon Rupture, Achilles Tendon, Achilles Tendon Repair Introduction/Purpose: Peroneal tendon disease (PerTD) is a major cause of lateral ankle pain, including...

Abstract Background Apoptosis is a fundamental biological process and a central determinant of therapeutic response in breast cancer (BC). Resistance to immunotherapy is increasingly recognized to be driven, in part, by ...

BackgroundArtificial intelligence (AI) has substantial potential to advance periodontal and peri- implant care through novel diagnostic, prognostic, and therapeutic opportunities. Nevertheless, the evidence is scattered ...

Abstract Using biomedical foundation models (FMs) for inference on small cohorts, represents a promising and practical route to advance drug response biomarker discovery and target identification. Here, we demonstrate th...

Abstract Background The complex relationship between the gut microbiome and immune system development during infancy is considered a key factor in the rising rates of pediatric allergic diseases. Food protein-induced all...

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

Abstract Background Subcortical structures are pivotal for cortico-subcortical communication, yet are highly vulnerable to stroke. Damage to these structures can produce widespread cortical dysfunction, but how subcortic...

Abstract Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG) systems have significantly advanced data modelling capabilities and improved opportunities for extracting knowledge from vast and heterogeneo...

Early detection of Parkinson’s disease (PD) through speech analysis offers significant clinical advantages, yet no validated tools exist for Arabic-speaking populations, representing a critical gap in global healthcare...

Abstract Chronic pain is a multifactorial condition often accompanied by comorbidities such as anxiety, depression, and cardiovascular dysfunction. Traditional injury-based models have provided valuable mechanistic insig...

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that plays a pivotal role in DNA repair and the maintenance of genomic stability. The discovery of synthetic lethality in tumors with homologous recombination...

Abstract Background Metabolic syndrome (MetS) obviously increases the risk of major adverse cardiac and cerebrovascular events (MACCE) in patients with acute myocardial infarction (AMI). However, the metabolic mechanisms...