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Background. Oral isotretinoin is an indispensable treatment for patients with resistant and severe acne vulgaris, both in South Africa (SA) and globally. While routine laboratory monitoring is often deemed unnecessary fo...

Early diagnosis of primary immunodeficiency (PID) remains a significant clinical challenge, often delaying treatment and increasing the risk of severe infections. Accurate identification of antibody (Ab) deficiencies typ...

BackgroundAlzheimer’s disease (AD), the most prevalent dementia, is primarily underpinned by the amyloid cascade hypothesis. Passive Aβ immunotherapy effectively reduces cerebral Aβ deposition but is limited by sever...

BackgroundThe prevalence of chronic diseases among the Chinese occupational population is rising steadily, with hypertension and diabetes becoming important health concerns. Occupational health examinations (OHE) provide...

As part of an on-going long-term study on the reproductive ecology and health status of imperial cormorants (Phalacrocorax atriceps), blood samples were collected to establish baseline values for hematological parameters...

Abstract Background Recent studies have investigated dogs with presumed diet‐associated dilated cardiomyopathy (daDCM), but prospective studies of multiple breeds are needed. Hypothesis/Objectives To evaluate baseline ...

Abstract Background Reference intervals for platelets and white blood cell (WBCs) counts are lower in greyhounds than other breeds. Proteinuria is common. Vector‐borne diseases (VBD) cause thrombocytopenia, leukopenia,...

BackgroundPhosphoinositide 3-kinase δ (PI3Kδ) is a lipid kinase that is composed of a catalytic subunit (p110δ, PIK3CD) and a regulatory subunit (p85, PIK3R1) and mediates signal transduction downstream of multiple im...

Non-lethal biological techniques such as blood biomarkers have gained attention due to their value as early signals of anthropic effects of contamination representing significant tools to evaluate ecosystems health. We e...

Abstract Background Improved understanding of Bartonella spp. serology in dogs may aid clinical decision making. Objective Describe demographic and geographic patterns of Bartonella spp. seroreactivity in dogs, and descr...

BackgroundNewborn screening (NBS) with kappa-deleting recombination excision circles (KRECs) is primarily used to detect B cell lymphopenia and agammaglobulinemia as markers of inborn errors of immunity (IEIs). However, ...

ABSTRACT Background Substance use, particularly cannabis and alcohol consumption, presents a growing public health challenge in Ghana, with significant implications for both mental and physical health. While the adverse ...

Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may cause stress-induced transient acute cardiac dysfunction through myocardial stunning, in the form of exacerbation-triggered Takotsubo ...

ABSTRACT Background Revisiting the association between heart disease and renal infarction (RI) in cats is relevant to determine whether those with RI should undergo echocardiographic screening. Objective Compare the rela...

OBJECTIVE: We aimed to evaluate the ECG fi ndings in asymptomatic HD patients for CVD, and to determine related factors with these fi ndings. MATERIAL and METHODS: 545 maintenance HD patients treated at 10 different HD...

BackgroundCo-exposure to noise and microwave radiation occurs frequently. The central nervous system has been identified as a sensitive target organ for both noise and microwave exposure individually, and the underlying ...

Objective To assess the effectiveness of belimumab (BEL) in improving anaemia, thrombocytopenia, lymphopenia and leucopenia in patients with SLE.Methods The BeRLiSS (Belimumab in Real Life Setting Study) 2.0 cohort inclu...

ABSTRACT Background Ehrlichia, Hepatozoon, and Babesia have the potential to cause life‐threatening illnesses in dogs, especially when coinfections occur. Hypothesis/Objectives To determine the infection rates, coinfec...

Abstract Background Malignant hyperthermia (MH) is associated with mutations in the RYR1 gene; however, the effect of volatile anesthetic concentrations on the clinical symptoms of patients with MH is unknown. We investi...

Abstract Background Gallbladder mucocele (GBM) is a common biliary disorder in dogs. Limited information is available on the coagulation status of dogs with GBM. Hypothesis/Objectives To determine patterns of coagulation...

Background Doxorubicin is a common antineoplastic agent with dose‐dependent cardiotoxic adverse effects, and pre‐existing myocardial dysfunction is a contraindication to its use. Objectives To systematically define t...

Unexplained coagulopathy with persistent anemia presents a significant diagnostic challenge and requires a broad differential. Isolated coagulation factor deficiencies are uncommon and described only sporadically in the ...

BackgroundNewborn screening for severe combined immunodeficiency (SCID) using T cell receptor excision circles (TRECs) enables early detection of disorders affecting T cell development. While low TRECs typically indicate...

Abstract Objective: To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS). Methods: A cross-sectional study was conducted with ...