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Aims: The aims were to assess the influence of tibial bone mineral density (BMD) and cement viscosity on cement mantle thickness in total knee arthroplasty (TKA), and to determine whether BMD is a more dominant factor th...

Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double...

Abstract Objective To explore the utility of microarray technology in prenatal diagnosis of nasal bone agenesis or hypoplasia. Methods Between July 2018 to October 2023, several cases of abnormal nasal bone development w...

IntroductionFamilial partial lipodystrophy (FPL) is a rare condition related to partial deficiency of adipose tissue and consequent insulin resistance resulting in metabolic alterations. Although type 2 diabetes mellitus...

Type 2 diabetes mellitus (T2DM) is associated with disturbances in bone metabolism that may increase fracture risk, even in the presence of normal or high bone mineral density (BMD). Dyslipidemia and elevated leptin leve...

ABSTRACT Understanding how skeletal muscle influences bone formation is essential for uncovering the mechanisms of muscle‐bone communication and developing therapies for osteoporosis. Here, we demonstrate that extracel...

This study aimed to evaluate the performance of deep learning models for segmenting the augmented bone following transalveolar sinus floor elevation (TSFE). Cone-beam computed tomography (CBCT) data from 103 patients und...

Abstract Bone defects resulting from trauma, tumors, or infection continue to pose significant clinical challenges, particularly when the defect size exceeds the capacity for spontaneous healing. In this study, we fabric...

Abstract Objectives Pre-surgical orthodontic decompensation (POD) for patients with skeletal Class III malocclusion may lead to alveolar bone loss. This study investigates the relationship between vertical facial pattern...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...

Objective: This study evaluated natural bone healing after cystectomy without the aid of a bone graft using clinical examination and panoramic radiographs. Materials and Methods: We recruited ten individuals who presente...

ObjectiveThis study aimed to investigate the long-term effects of chronic sleep deprivation (CSD) on the bone mineral density (BMD), bone microarchitecture, biomechanical properties and body weight of middle-aged and old...

Abstract Introduction Bone and joint infections (BJIs) are complex and difficult to eradicate, and have high relapse rates and limited oral treatment options. Tetracyclines combine favorable bone penetration, oral bioava...

Abstract Objectives To evaluate the clinical utility of “multi-echo recombined gradient echo” (MERGE)-based bone-like MRI for delineating acetabular osseous morphology in developmental dysplasia of the hip (DDH), and...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

ABSTRACT Bone injuries, particularly those associated with an aging global population, pose a persistent and complex clinical challenge. Current gold‐standard treatments such as autografts, allografts, and metal implan...

ABSTRACT Objectives Talar cysts, a common manifestation of osteochondral lesions of the talus (OLT), often result from trauma and cause significant pain and dysfunction. Cysts > 10 mm require grafting, and autologous...

Abstract Critical-sized bone defects possess inherently limited self-healing potential, posing a persistent challenge in clinical bone repair. In recent years, numerous hydrogel systems have been developed for bone defec...

Abstract Background Current bone tissue engineering scaffolds face challenges such as inadequate mechanical support, limited biocompatibility, and suboptimal osteogenesis for treating critical-sized bone defects. This st...

Bone infection is a severe disease caused by microbial invasion of bone tissue, characterized by inflammatory responses, bone destruction, and impaired repair. Its high recurrence rate and refractory nature have posed si...

Abstract Background Matrix stiffness is a key feature of the mechanical microenvironment. Periodontal tissue is a multicomponent structure composed of cementum, periodontal ligament, and alveolar bone, and is essential f...

A pathological shift in bone marrow mesenchymal stem cell (BMSC) differentiation towards adipogenesis at the expense of osteogenesis is a key cellular driver of osteoporosis induced by glucocorticoids or estrogen deficie...

IntroductionBone defect repair remains a clinical challenge due to the complex inflammatory microenvironment that regulates mesenchymal stem cell fate.MethodsBased on our previous work demonstrating that quercetin-loaded...