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Abstract The prognostic impact of age in bone-only metastatic prostate cancer (BoM-PCa) remains insufficiently characterized. This study evaluated the association between age and cancer-specific mortality (CSM) in a popu...

ABSTRACT Although chemotherapy‐induced bone loss is well‐recognized during breast cancer treatment, the underlying mechanism remains to be further elucidated, especially in patients with obesity. In this study, the o...

Bone metastasis is a frequent and incurable consequence of advanced prostate cancer (PC). This process originates through an interplay between disseminated tumor cells and heterogeneous bone resident cells in the metasta...

Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double...

ABSTRACT Background Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongo...

Abstract Background Although [¹⁸F]PSMA-1007 enables sensitive detection in prostate cancer, heterogeneity in PSMA expression and variable physiologic uptake can limit performance, whereas [¹⁸F]FAPI-42, targeting fi...

Abstract Histone deacetylases (HDACs) are critical epigenetic regulators that play pivotal roles in tumorigenesis and cancer progression. Class I HDACs have garnered significant attention due to their essential functions...

Abstract Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radioth...

Introduction Bone metastasis in breast cancer patients can lead to poor quality of life and cause significant morbidity. First-line treatments for bone metastases include bone modifying agents that inhibit osteoclast act...

BackgroundNewborn screening for severe combined immunodeficiency (SCID) using T cell receptor excision circles (TRECs) enables early detection of disorders affecting T cell development. While low TRECs typically indicate...

Hypereosinophilic syndrome (HES) is characterized by blood or tissue hypereosinophilia leading to organ damage or dysfunction. HES is most commonly secondary or idiopathic, but may be primary (myeloid) or familial. Here,...

Introduction: The American College of Radiology (ACR) Bone-Reporting and Data System (Bone-RADS) gave a structured framework for assessing and reporting bone tumours. Aim: To evaluate the diagnostic performance of the...

Cyclophosphamide (CP) is commonly used in cancer chemotherapy and the treatment of autoimmune diseases. In clinical applications, it exhibits the side effect of progressive anemia. Donkey serum albumin (DSA) is the most ...

The characteristic oral environment – with its dynamic clearance, moisture, microbial load, and inflammatory potential – makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks ...

Abstract Tumor-associated macrophages can either promote or suppress cancer, but therapeutic targeting remains challenging because we lack a predictive framework for macrophage function. The prevailing M1/M2 paradigm ove...

Abstract Ewing sarcoma (EWS), a rare pediatric bone tumor, poses unique therapeutic challenges due to its distinct microenvironment and limited molecular understanding. To gain a comprehensive molecular and functional vi...

Abstract Background Myeloid epithelial reproductive tyrosine kinase (MERTK) receptor is overexpressed in cancers and is associated with poor prognosis. RGX-019-MMAE, a novel humanized IgG1-MMAE antibody-drug conjugate (A...

Multiple myeloma is a plasma cell neoplasm that accounts for approximately 1% of all tumors in dogs and is more commonly diagnosed in elderly animals. Clinical signs are generally nonspecific and may include bone pain, l...