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En esta publicación se han resumido los principales trabajos de investigación científica sobre carcinogénesis realizados en el Centro de Investigaciones Biológicas (Hospital Interzonal General de Agudos "Prof. Dr. L...

Diet and the gut microbiome are major, interdependent determinants of colorectal cancer (CRC) risk. This review discusses current evidence on how dietary patterns reshape microbial ecology, modulate microbial virulence, ...

Sleep is a biological manifestation which there is a periodic alternation between synchronized and desynchronized cerebral electrical activity. Although sleep occupies approximately a third of the human lifespan, the amo...

Hemozoin (Hz) is a crystalline by-product, which is produced when the Plasmodium species destroy haemoglobin, and it is commonly recognised that it leads to how our bodies respond to malaria. Although we understand prett...

Abstract Among the epidermal growth factor receptor tyrosine kinases (EGFR) family, HER3 (Human epidermal growth factor receptor3) stands apart due to its minimal inherent intracellular kinase function. Its kinase domain...

Materias / palabras clave: Genes; Mutación; Cáncer; Cancer; Oncogenes; Carcinogenesis

Caffeine is one of the most widely used ergogenic aids in sport, known for its performance-enhancing effects on endurance, strength, and cognitive function. Beyond these well-established roles, emerging evidence suggests...

Abstract Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants of global concern due to their widespread occurrence, environmental persistence, and well-documented adverse effects on human health. In ...

La vida de nuestro laboratorio es tan extensa como la mía, pues ambos nacimos el mismo año. Y no son pocos los años que llevo trabajando aquí, desde 1983. Los tiempos más felices de mi actividad profesional han sido...

Abstract Laryngeal cancer (LC) is one of the malignant tumors affecting the head and neck region. 5-methylcytosine (m5C) is a common RNA modification that contributes to the carcinogenesis process. Aly/REF export factor ...

A introdução da profilaxia da transmissão vertical do HIV com o uso de drogas anti-retrovirais aliadas a outras medidas resultou na redução de crianças infectadas pelo HIV em nosso meio. Esses medicamentos são de ...

The escalating global prevalence of antibiotic-resistant Helicobacter pylori strains has undermined conventional eradication therapies, heightening the burden of associated conditions such as gastritis, peptic ulcers and...

Cancers of the gastrointestinal tract represent a significant public health concern. Due to the increasing prevalence of these conditions, promoting knowledge about cancer-associated manifestations is crucial. Among thes...

Abstract DIS3, a key nuclear RNA-degrading enzyme, is essential for immunoglobulin class switch recombination (CSR), promoting activation-induced cytidine deaminase (AID) activity on both DNA strands to induce double-str...

The effect of soursop leaves (Annona uricata linn) ethanolic extract on micronucleus frequency  of buccal mucosa epithelium of Sprague dawley rats. Polycyclic aromatic hydrocarbons is one of the largest  groups of carc...

ObjectivePancreatic disorders are characterised by high mortality rates and limited therapeutic options and pose a global health challenge. As a dual-function organ with endocrine and exocrine roles, the pancreas exhibit...

Colitis-associated colorectal cancer (CAC) represents the most severe malignant complication of inflammatory bowel disease (IBD), characterized by high invasiveness, frequent recurrence, and poor prognosis. Recent studie...

Evidence shows that oral glycerol supplementation during the early stages of rat liver cancer reduces the growth of preneoplastic lesions. Besides, human hepatocellular carcinoma (HCC) cells display decreased expression ...

Abstract Papillary Thyroid Cancer (PTC) is one of the most prevalent endocrine malignancies, and its incidence rate has almost tripled over the past three decades. The current study aimed to identify gene alterations and...

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Colonic polyps are known to be potential precursors to CRC. Evaluating cellular proliferative activity across various polyp types and...

Our aim was to evaluate whether chronic administration of CAF affects the uterus and induces the morphological and molecular changes associated with endometrial hyperplasia. Female Wistar rats exposed to CAF from weaning...

Psoriasis and psoriatic arthritis are chronic immune-mediated disorders associated with substantially impaired quality of life and comorbidities. Janus kinase (JAK) inhibitors have recently emerged as highly efficient th...

Abstract Background Lung squamous cell carcinoma (LUSC) is one of the common pathological subtypes of non-small cell lung cancer, which poses significant treatment challenges due to poor response to conventional therapie...

Abstract Breast cancer is still the most significant contributor to morbidity and mortality among women in China. Despite advances in imaging and molecular testing, few reliable biomarkers exist for early detection and d...