Buscar recursos académicos

IntroductionThe limited availability of suitable scaffolds for three-dimensional (3D) cell culture has driven the development of new biomaterials. In this study, we developed a porcine fibrin matrix gel (PFMG) derived en...

The development of anti-CD3 antibody-based T cell engager therapeutics has improved the treatment of various malignancies, yet the challenge of achieving tumor-specific targeting while minimizing on-target off-tumor effe...

Abstract Background Cumulus granulosa cells (CGCs) are essential for oocyte support, metabolic cooperation, and steroidogenesis, yet they deteriorate rapidly in conventional 2D culture, limiting long-term studies of thes...

Abstract Background The ability to guide stem cells toward the bone-forming lineage is a fundamental aspect of regenerative medicine. Conventional protocols for osteogenic differentiation of mesenchymal stem cells typica...

Biofabricated scaffolds facilitate bona fide cellular interactions, cell type specification, and the formation of three-dimensional tissue architecture from human pluripotent stem cells (hPSCs). However, xenogenic biomat...

This study aims to examine the role of exosomes derived from human urine-derived stem cells (hUSCs-Exo) in the in vitro construction of a composite structure comprising hUSCs and a porcine urethral decellularized matrix...

Colorectal cancer (CRC) ranks third in incidence among all malignancies and is highly lethal in advanced stages. Combination chemotherapy regimens based on 5-fluorouracil (5-FU) remain the mainstay of colorectal cancer t...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

Abstract Bone defects present significant challenges in clinical practice due to the limitations of traditional treatments. Compared to traditional cell therapies, exosome-based therapies have emerged as a promising alte...

The rising concern of antimicrobial resistance, coupled with the continually challenging management of complicated diseases such as cancer, has provided momentum toward precision molecular medicine. This review provides ...

Abstract Background Electrical stimulation of cell culture systems has shown significant potential benefits, attracting growing interest in bioelectrical research and tissue engineering. However, implementing effective s...

In the biomedical field, polyethylene glycol-based materials demonstrate remarkable positive potential as drug delivery systems, in wound healing, and tissue engineering. It’s known that complex of polyethylene glycol ...

Abstract Background Current bone tissue engineering scaffolds face challenges such as inadequate mechanical support, limited biocompatibility, and suboptimal osteogenesis for treating critical-sized bone defects. This st...

Abstract Bone tissue engineering scaffolds must provide structural support while permitting fluid transport and maintaining safe hydrodynamic conditions for cell activity. Triply Periodic Minimal Surface (TPMS) architect...

Abstract Background and objectives Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) has emerged as a promising target for cancer immunotherapy, given its overexpression in various malignancies and low or a...