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IntroductionThe limited availability of suitable scaffolds for three-dimensional (3D) cell culture has driven the development of new biomaterials. In this study, we developed a porcine fibrin matrix gel (PFMG) derived en...

The constitutive androstane receptor (CAR) modulates the transcription of numerous genes involving drug metabolism, energy homeostasis, and cell proliferation. While rodent studies suggest an oncogenic role for murine CA...

Porcine circovirus type 2 (PCV2) is a significant immunosuppressive pathogen that poses a serious threat to the global swine industry. PCV2 infection often triggers secondary infections with multiple pathogens, making it...

Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy lacking reliable prognostic biomarkers and effective therapeutic targets. TMEM72, a kidney-enriched protein, is dysregulated in RCC, yet its bio...

Abstract Background Metformin has emerged as a potential bioactive agent in regenerative medicine; however, its optimal concentration for enhancing dental pulp stem cell (DPSC) function remains unclear. This study evalua...

Abstract Sugen kinase 495 (Sgk495), also known as Serine/Threonine Kinase 40 (STK40), is a pseudokinase previously implicated in T cell differentiation via regulation of Foxo transcription factors. However, its function ...

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Colonic polyps are known to be potential precursors to CRC. Evaluating cellular proliferative activity across various polyp types and...

Abstract Congenital pulmonary airway malformation (CPAM), especially type I, is an uncommon developmental lung defect marked by abnormal proliferation of pseudostratified ciliated columnar epithelium (PCCE) and the prese...

Abstract Aim Periodontitis can impair the osteogenic function of periodontal ligament stem cells (PDLSCs), thereby compromising their capacity for periodontal tissue regeneration. In this study, we explored the impact of...

Background: Mantle cell lymphoma (MCL) exhibits distinct biological characteristics and marked molecular heterogeneity, with TP53 mutations associated with particularly poor clinical outcomes. Eprenetapopt (APR-246), a f...

This study aims to examine the role of exosomes derived from human urine-derived stem cells (hUSCs-Exo) in the in vitro construction of a composite structure comprising hUSCs and a porcine urethral decellularized matrix...

Abstract Folate (FA), essential for DNA synthesis, repair and methylation, is predominantly stored and metabolized in the liver. Dysregulation of folate intake and metabolism is strongly implicated in the pathogenesis of...

Abstract Lung cancer remains the leading cause of cancer incidence and mortality globally, yet its molecular mechanisms remain poorly understood. Recent studies highlight the role of protein lactylation in regulating tum...

Abstract Background I Kappa B Kinase Interacting Protein (IKBIP) has been reported to promote tumor progression in diverse cancers. however, the role of IKBIP in hepatocellular carcinoma (HCC) has remained unclear. Metho...

Abstract Histone deacetylases (HDACs) are critical epigenetic regulators that play pivotal roles in tumorigenesis and cancer progression. Class I HDACs have garnered significant attention due to their essential functions...

BackgroundTransmembrane Emp24 Domain Containing 2 (TMED2) is involved in various cancers, but its role in diffuse large B-cell lymphoma (DLBCL) remains unclear. This study investigated TMED2’s expression, biological fu...

Abstract Dysfunction of epithelial cell contacts associates with a myriad of human diseases. Cisplatin is an effective antineoplastic agent where it interferes with DNA replication in proliferating cells, but it causes k...

Leiyu Cao,* Xingfang Wei,* Yu Wei, Xiaoli Ma, Yan Gao, Chengcheng Qu, Wen Yi, Kalima Muhetaer, Li Zhang Cadre Healthcare Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinji...

Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and poor prognosis. This study integrates bioinformatics with experimental validation to cha...

Abstract Background Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality. This study examines whether the deubiquitinase USP4 promotes NSCLC progression by stabilizing PAF1 and opposing the E3 ligase...

Abstract Background Adipose tissue is increasingly recognized as an important component of the tumor microenvironment of colorectal cancer (CRC) and actively contributes to the progression of the disease. Adipose stem ce...

Background23-Hydroxybetulinic acid (23-HBA), a key bioactive compound in the traditional Chinese herb Pulsatilla chinensis, has garnered substantial scientific interest due to its potent antitumor activity. However, the ...

Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...