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Abstract Background/objectives Cardiovascular diseases (CVDs), particularly myocardial infarction (MI) and heart failure (HF), remain global causes of morbidity and mortality, despite the current treatment options. Stem ...

Abstract Tuberculosis (TB) remains a major global public health challenge, with drug-resistant tuberculosis (DR-TB) presenting a serious threat to TB management. Conventional treatment faces challenges such as significan...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

Ziyuan Shen,1 Xing Xing,2 Kang Rong,3 Ziyang Geng,4 Ning Yang,5 Linyan Xu,3,6 Hongfeng Ge,7 Wei Sang3,6,8 1Clinical Research Institute, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Re...

Clinical trials of adoptive cellular therapy demonstrate that a key characteristic associated with durable responses is in vivo expansion and persistence of transferred T cells. Strategies to develop a less differentiate...

Abstract Background Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who failed bispecific antibody (BsAb) therapy face an extremely poor prognosis, necessitating exploration of effective salva...

Xiaoying Quan, Lei Lei, Xiaoyan Chen, Xiaoli Jia, Chunzhi Wu, Bin Ye, Qiyue Huang, Min Luo, Ning Wang, Jiayang Yu, Lifu Feng Department of Medical Oncology, the Sixth People’s Hospital of Chengdu, Chengdu, Sichuan, 610...

Aleksander Kielbik,1– 3 Veronika Bahlinger,3,4 Christian M Schürch,3,4 Maria Luisa Barcena,2 Olesya Vakhrusheva,2 Anita Thomas,5 Igor Tsaur,2 Jonas S Heitmann,1,3 Helmut R Salih,1,3,6 Ilona Hagelstein1,3,6 1Clinical C...

Abstract Background Patients with locally advanced head and neck squamous cell carcinoma are receiving adjuvant radio(chemo)therapy as standard of care, according to national guidelines. However, patients with human papi...

Background: Targeted radioligand therapy (TRT) is an emerging theranostic modality in oncology. While well established in neuroendocrine and prostate cancers, its role in small cell lung cancer (SCLC) and non-small cell ...

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the head and neck region, where conventional therapies have limited efficacy and patients have poor prognosis. As newly identified metal i...

INTRODUCTION: In vitro studies indicate that UV radiation causes photoaging in the skin through oxidative stress, collagen destruction, DNA damage, and chronic inflammation. These models play a critical role in the devel...

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

IntroductionTherapies for metastatic renal cell carcinoma (mRCC) have evolved significantly, making treatment decisions more complex. We used machine learning (ML) to identify subgroups of patients who have a high probab...

Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...

Background: Neoadjuvant chemoradiation therapy (nCRT) has survival benefits for patients with cT1N1 or cT2–3N0-1 esophageal squamous cell carcinoma (ESCC), but heterogeneous disease behavior has been observed in node...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

Iman Owliaee,1 Ali Teimoori,1 Mohammad Shoushtari,2 Ali Shojaeian3 1Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Virology, Pasteur Institute o...

Bladder cancer is a highly malignant tumor with limited treatment options. Although adoptive cell therapy has shown promise in oncology, its efficacy is often constrained by poor intrinsic antitumor activity and a highly...

Abstract Intracerebral hemorrhage (ICH) is a devastating neurological condition with high mortality and morbidity. Despite advancements in medical and surgical treatments, the long-term prognosis of ICH remains poor. Ste...

Abstract The field of regenerative medicine for Parkinson’s disease (PD) has reached a pivotal moment. After decades of preclinical research, recent first-in-human clinical trials demonstrated that cell replacement the...

Abstract Inorganic nanoparticles and bee venom are emerging anticancer agents with potential for tumor‑selective cytotoxicity and immune modulation. This study aimed to compare the anticancer activity of three inorgani...