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Elucidation of the cellular functions of RNAs represents one of the most exciting research areas in modern life sciences. RNAs play crucial roles in plant biology, including developmental regulation and environmental res...

N6-methyladenosine (m6A) is a major post-transcriptional RNA modification, and the demethylase ALKBH5 has emerged as a versatile but highly context-dependent regulator of RNA fate. This review integrates current evidence...

Materias / palabras clave: adiposity; chronic diseases; MASH; MASLD; metabolic syndrome; obesity

Raman scattering can provide information on molecular fingerprints, which have been widely applied in various fields of material science and nanobiotechnology. Notably, low interference with water molecules in obtaining ...

Xenopus laevis oocytes were injected with [14C] phe-tRNA and the fate of the aminoacyl moiety was studied. The radioactive phenylalanine is gradually hydrolized off the tRNA once inside the cell. The rate of deacylation ...

Abstract Background Protein-protein interaction (PPI) network-based protein function prediction algorithms, which use the guilt-by-association principle, are widely applied in medical and human domains, but they are comp...

ABSTRACT Cells rely on surface receptors to sense and initiate signalling cascades essential for numerous cellular processes, but engineering of synthetic genetic circuits to sense and rewire receptor activities for user...

Abstract Abdominal aortic aneurysm (AAA) is a common cardiovascular disease resulting in high mortality rate due to rupture. Intraluminal thrombus (ILT) is involved in AAA progression via both biomechanically protective ...

Abstract Nuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus a...

This work explores the intricate process of osmoregulation in Trypanosoma cruzi, the causative agent of Chagas disease, with a specific focus on the mechanisms of fluid discharge by the contractile vacuole complex (CVC) ...

Abstract Left-sided colorectal cancer (LCRC) and right-sided colorectal cancer (RCRC) show marked differences in prognosis and therapeutic response, yet the underlying molecular mechanisms remain poorly understood. We hy...

In living organisms, production of reactive oxygen species (ROS) is counterbalanced by their elimination and/or prevention of formation which in concert can typically maintain a steady-state (stationary) ROS level. Howev...

ABSTRACT A systems biology approach was used to characterize Monotropa uniflora, a nonhotosynthetic, myco‐heterotrophic plant. In contrast to autotrophic plants, myco‐heterotrophic plants obtain carbon and other nutr...

Abstract Cuproptosis is a recently identified copper-dependent cell death pathway with growing relevance in tumor biology, yet its involvement in thyroid carcinoma (TC) remains poorly understood. In this study, we integr...

Transient hypoxia in pregnancy stimulates a physiological reflex response that redistributes blood flow and defends oxygen delivery to the fetal brain. We designed the present experiment to test the hypotheses that trans...

Abstract Background Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now r...

Abstract Fibrous dysplasia (FD) is a rare disorder associated with fractures and deformities. FD lesions produce excess phosphaturic hormone fibroblast growth factor 23 (FGF23), leading to hyperphosphaturia in most patie...

This study demonstrates up-regulation of alveolar macrophages expressing genes important for inflammation and lipid metabolism in people with cystic fibrosis, identifying potential therapeutic targets. Cystic fibrosis (C...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) are found in nearly one-third of patients. Using a cellular co-culture system including neurons and human microglia infected ...

The present study presents the first characterization of a full cytohesin-2 knockout and establishes cytohesin-2 as a critical factor for perinatal development, identifying a previously unrecognized role of cytohesin-2 i...

Abstract Background Gas-phase bioprocesses that immobilize microbial cells on solid carriers enable efficient conversion of volatile or poorly water-soluble substrates. Acinetobacter sp. Tol 5 is a highly adhesive bacter...

This study represents one of the first investigations of circular RNAs (circRNAs) in the ovaries of Tibetan sheep, with a focus on their potential role in reproductive performance. The aim was to identify circRNAs involv...

Abstract Background Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the ...