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Abstract Bacteria adjust their metabolism to the cellular energy state. AMP-forming acetyl-CoA-synthetase AcsA generates acetyl-CoA from acetate, ATP and CoA. In Bacilli, including Bacillus subtilis and Geobacillus stear...

Materias / palabras clave: Science: Mathematics: Instruments and machines; Technology: Engineering (General). Civil engineering (General): Applied optics. Photonics; Social Sciences: Transportation and communications: Cellular telephone services i...

Abstract This paper originates from a practical experiment based on Mesh Networks. The promising results obtained from this experiment prompted us to discuss in greater depth whether Wireless Local Area Networks (WLAN) a...

Abstract Low-Earth orbit (LEO) satellites encounter significant energy challenges during eclipse periods and low solar illumination, limiting mission autonomy, operational lifespan, and functionality. This paper presents...

Abstract Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HH...

Abstract Focal cortical dysplasia (FCD) is a predominant cause of drug-resistant epilepsy in children, yet the neuro-immune mechanisms underlying this condition are not well understood. Through transcriptomic screening c...

Abstract Inducing protein oligomerization holds therapeutic promise, yet identifying or rationally designing effective inducers remains challenging. In this study, we leverage nanopore technology to screen small molecule...

Abstract Transcriptional regulation, critical for cellular differentiation and adaptation to environmental changes, involves coordinated interactions among DNA sequences, regulatory proteins, and chromatin architecture. ...

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent cause of chronic liver disease worldwide, currently lacks precision medicine treatments. SLCO4C1 acts as a transporter for end...

Environmental sustainability (ES) is increasingly shaped by technological advancement, particularly through the diffusion of information and communication technologies (ICT). While ICT has the potential to improve enviro...

Abstract Cattle are the mammalian species with most global biomass, encompass the two subspecies Bos taurus and Bos indicus, which are phenotypically distinguishable and have distinct genetic backgrounds. We used fresh p...

Abstract GH 3230 superalloy is a solution strengthening nickel-based superalloy and it is commonly used for fabricating hot components with the service temperature of above 900 ℃. In order to further improve high-tempe...

Abstract Background Exercise training often produces less weight loss than expected, a phenomenon termed exercise-induced energy compensation, but the underlying mechanisms remain unclear. This study aimed to quantify me...

Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in livi...

Abstract Mutations in the presenilin (PS/PSEN) genes cause early-onset familial Alzheimer’s disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) peptides and microtubule-associated protein tau (MAPT). Ho...

Abstract Genetic interaction and protein-protein interaction networks have proved among the most important tools for inference of gene function and genotype-phenotype relationship. It remains unclear, however, how these ...

Abstract Mosaic variegated aneuploidy (MVA), a rare human congenital disorder that causes microcephaly, is characterized by extensive abnormalities in chromosome number and results from mutations in genes involved in acc...

Abstract Spinster homolog 2 (SPNS2) exports the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) out of cells to regulate processes important for health and diseases. However, the molecular mechanism under...

Abstract Aging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders. Here we report in vitro screening outputs from a natural...

Abstract Glucocorticoid-producing cells of the adrenal cortex (i.e. zona fasciculata, zF) constitute the critical effectors of the hypothalamic-pituitary-adrenal axis, mediating the mammalian stress response. With glucoc...

Abstract Ticks transmit diverse pathogens and secrete saliva with immunomodulatory properties that facilitates blood feeding. However, the cellular mechanisms underlying saliva-mediated immune suppression remain poorly d...

Abstract Recent advancements in single-cell DNA methylation (scDNAm) sequencing technologies have enabled the profiling of epigenetic landscapes at unprecedented resolution, offering insights into cellular heterogeneity,...

The rapidly expanding technology of cellular communications, wireless local area network (LAN), wireless data networks and satellite gives mobile users the ability of accessing information anywhere and anytime. Data broa...

The publication of Mobile IPv6 RFC 3775 by the IETF is a breakthrough in the data communications industry to achieve the technology convergence required by ubiquitous mobile devices. MIPv6 not only brings the possibility...