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Materias / palabras clave: cytopathology, cytology, pathology; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology

Materias / palabras clave: oncology, molecular oncology, cellular oncology, oncogenesis, cancer; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Abstract Background Disruption of cellular proteostasis leads to the accumulation and persistence of pathogenic proteins that drive oncogenesis. Key oncogenic and tumor suppressor proteins are frequently dysregulated in ...

ABSTRACT The growing interest in transferring therapeutic advances from human to veterinary medicine has spurred research into monoclonal antibodies and advanced therapies for treating cancer in small animals. This syste...

BackgroundSmall Nuclear Ribonucleoprotein Polypeptide A (SNRPA), an RNA-binding protein associated with HCC survival, emerges as a key regulator requiring mechanistic study.MethodsTo delineate SNRPA’s functions, we gen...

Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy lacking reliable prognostic biomarkers and effective therapeutic targets. TMEM72, a kidney-enriched protein, is dysregulated in RCC, yet its bio...

Hailing Pan,1,* Zixin Huang,2,* Aiping Li,1 Meiya Li,3 Yanxing Li,1 Ya Lin,1 Jiayin Cai1 1Department of Oncology, Traditional Chinese Medical Hospital of Wenling Affiliated to Zhejiang Chinese Medical Uni...

Abstract Background Hepatocellular carcinoma (HCC) is a critical condition characterized by unchecked cellular growth in the liver, often leading to systemic inflammation and organ failure. Although its complex molecular...

ObjectiveTo systematically evaluate the efficacy of Traditional Chinese Medicine (TCM) as an adjunctive modality in postoperative ovarian cancer management, specifically focusing on its capacity for toxicity reduction an...

Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite mul...

Metabolic alteration has emerged as a hallmark of cancer, reshaping cellular energetics and biosynthetic pathways through enzyme denaturation, mutations, acidic pH, and hypoxia to sustain uncontrolled proliferation. Unde...

Abstract Left-sided colorectal cancer (LCRC) and right-sided colorectal cancer (RCRC) show marked differences in prognosis and therapeutic response, yet the underlying molecular mechanisms remain poorly understood. We hy...

BackgroundAdjuvant immune checkpoint inhibitors (ICI) have improved survival in stage III cutaneous melanoma, yet many patients do not benefit. The tumor microenvironment is pivotal for durable responses; defining cellul...

BackgroundGranular cell astrocytoma (GCA) is a rare, morphologically distinct variant of IDH-wildtype glioblastoma that can appear deceptively low-grade yet behave aggressively. Its molecular features remain poorly defin...

Abstract Background Collagenous fibroma (CF), also known as desmoplastic fibroblastoma, is a rare benign fibroblastic/myofibroblastic tumor characterized by FOSL1/FOS rearrangements. CF typically presents as a solitary, ...

Abstract Background ATF3 was found to play a complex role in various cancers; however, its systematic function in kidney renal clear cell carcinoma (KIRC) and across pan-cancer contexts remained incompletely understood. ...

Abstract Epithelial-to-mesenchymal transition (EMT) is a complex and dynamic cellular process during which epithelial cells lose their polarity and cell adhesion capabilities and subsequently express mesenchymal stem cel...

Abstract Background CSNK1D is a member of the CK1 family and is characterized by high conservation and widespread expression. It plays a regulatory role in the maintenance of numerous cellular processes and is expressed ...

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

IntroductionSkin cancer, including basal cell carcinoma, squamous cell carcinoma, and melanoma, is one of the most common cancers worldwide. Matrix metalloproteinases are zinc-dependent proteolytic enzymes that play a cr...

BackgroundAcquired resistance to cisplatin-based chemotherapy is common in patients with gastric cancer (GC) and significantly limits treatment efficacy. The aim of this study was to investigate molecular features associ...

BackgroundGastric cancer (GC) exhibits marked epidemiological differences between European (EUR) and East Asian (EAS) populations, with significantly higher incidence rates in EAS. Circulating proteins represent promisin...