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Objective: Diabetic retinopathy (DR) is a major microvascular complication of diabetes. This study aimed to elucidate the protective effects of curcumin, a bioactive dietary compound derived from turmeric, and its underl...

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

Abstract Hedyotis diffusa Willd (HD) and Scutellaria barbata D.Don (SB) are widely used traditional Chinese herbs with detoxifying properties and anti-tumor activities. The HD-SB pairing demonstrated significant anti-tum...

A subset of nuclear receptors (NRs) function as permissive heterodimers with retinoid X receptor (RXR), defined by transcriptional activation in response to RXR agonist ligands. Permissive NR-RXR activation is generally ...

Abstract Chronic administration of glucocorticoids are being linked to an increased risk of osteoporosis. 5-Hydroxymethylfurfural (5-HMF) is a natural compound that possesses various biological activities, including oste...

Jayshree H Ahire,1 Qi Wang,2 Yongping Bao,2 Isabelle SR Storer,1,3 Stefan Bidula,1,3 Gary Rowley,3,4 Jason C Crack1 1School of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, Norfolk, UK; 2Norwi...

Abstract Background Disruption of cellular proteostasis leads to the accumulation and persistence of pathogenic proteins that drive oncogenesis. Key oncogenic and tumor suppressor proteins are frequently dysregulated in ...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

ObjectiveTo determine whether serum exosomal long non-coding RNA AC245100.4 has value for early diagnosis and prognostic stratification in acute pancreatitis (AP), and to examine its potential involvement in inflammation...

Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental drive...

Mitochondrial dysfunction is a convergent hallmark of biological aging and a mechanistically attractive target for gerotherapeutic development. Yet translation of mitochondria-focused interventions has been limited by pa...

S-palmitoylation, a key reversible lipid post-translational modification, entails the covalent conjugation of palmitic acid chains to the thiol groups of cysteine residues in proteins. This modification modulates protein...

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disorder characterized by diastolic dysfunction, metabolic dysregulation and limited therapeutic options. Post-translational modification...

BackgroundObesity is a global health concern closely associated with sedentary lifestyles and the consumption of hypercaloric, hyperpalatable diets. While these factors contribute to excessive food intake and weight gain...

Abstract Testicular sex cord stromal tumor (TSCST) is a rare testicular tumor with unknown molecular mechanisms, tumor microenvironment (TME) and limited therapeutic options. To define the molecular mechanism and potenti...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer; however, first-line therapeutic agents show limited efficacy in patients with advanced disease. Bioactive peptides have emerged as p...

Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems. There are no curative treatments for patients with silicos...

RationaleCancer remains one of the most formidable challenges in mordern medicine. Chemoresistance, particularly resistance to platinum-based agents, presents a major challenge in effective treatments. In response to thi...

Materias / palabras clave: drug design and discovery, clinical pharmacology, cellular pharmacology, neuropharmacology, drug misuse and addiction, biopharmaceuticals; Medicine: Therapeutics. Pharmacology

Materias / palabras clave: biomedical science, clinical chemistry, biochemistry, pharmacology, molecular and cellular biology, pathology; Medicine: Medicine (General)