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Materias / palabras clave: Science: Physiology; Science: Chemistry: Organic chemistry: Biochemistry

Materias / palabras clave: cancer, molecular biology, pathophysiology, cellular metabolism, cell growth, cell biology; Science: Physiology; Science: Chemistry: Organic chemistry: Biochemistry

A growing number of studies are now utilizing human organotypic brain slice cultures (OBSC), enabled by improved long-term culture protocols that support the investigation of human-specific cellular physiology. Human OBS...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Flow cytometry has become an important tool in the fields of veterinary, medicine, and biological sciences in general. However, in the introductory and even in advanced university degree courses, students do not have man...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pathways including autophagy, proteasome-mediated degradation, antioxidant defense, nutrie...

O músculo estriado esquelético é formado pela associação de fibras musculares com a matriz extracelular. Esse tecido possui alta plasticidade e o conhecimento das características morfológicas, da miogênese, e da ...

BackgroundNitric oxide (NO) is a signalling and physiologically active molecule in animals, plants and bacteria. The specificity of the molecular mechanism(s) involved in transducing the NO signal within and between cell...

Dapagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used for the treatment of diabetes, has been consistently associated with cardiovascular protection, including attenuation of ischemia/reperfusio...

Abstract Background The ecdysone receptor (EcR) is a central regulator of mosquito physiology, best known for its role in vitellogenesis. However, its contribution to antiviral defense and dengue virus (DENV) replication...

The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major ris...

This study investigates whether remodeling/enhancing the two vital proteins—hemoglobin and B3p—in erythrocytes with artificial interference can rejuvenate aged and damaged erythrocytes. Using Raman spectroscopy and S...

This work explores the intricate process of osmoregulation in Trypanosoma cruzi, the causative agent of Chagas disease, with a specific focus on the mechanisms of fluid discharge by the contractile vacuole complex (CVC) ...

BackgroundMyocardial ischemia/reperfusion (I/R) injury is a major challenge in reperfusion therapy for acute myocardial infarction, primarily due to excessive oxidative stress, inflammation, and cardiomyocyte apoptosis. ...

The senescence of the neuro-skeletal muscle system is typified by a gradual deterioration in muscle mass, strength, neuromuscular efficacy, and cognitive capabilities, which is further exacerbated by metabolic dysregulat...

BACKGROUND/AIMS: Human parvovirus B19 (B19V) may cause inflammatory cardiomyopathy (iCMP) which is accompanied by endothelial dysfunction. The B19V capsid protein VP1 contains a lysophosphatidylcholine producing phosphol...

BACKGROUND: Pulmonary endothelial injury is a critical process in the pathogenesis of acute lung injury (ALI) during sepsis. Heat shock protein A12B (HSPA12B) is mainly expressed in endothelial cells and protects against...

BACKGROUND/AIMS: The components of cigarette smoke (CS) have been implicated in the development of cancer as well as in cardiopulmonary diseases. We have previously reported increased oxidative stress in rat tissues indu...

Los factores de crecimiento forman un grupo de macromoléculas polipeptí- dicas, que presentan acciones específicas y potentes sobre la regulación de la proliferación, la muerte, la motilidad y la diferenciación de ...

El virus linfo-trópico de células T humano de tipo I (HTLV-I) es un retrovirus asociado entre otras enfermedades a la leucemia de células T del adulto y la paraparesia espástica tropical. La patología es aparentemen...

Materias / palabras clave: gastroenterology, clinical gastroenterology and hepatology, cell biology, immunology, physiology, microbiology; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenter...

Materias / palabras clave: general pathophysiological processes, cellular and molecular pathophysiology, renal and fluid and electrolyte pathophysiology, gastrointestinal and hepatic system, metabolic disorders, reproductive system; Science: Physi...

Materias / palabras clave: human physiology, molecular physiology, cellular physiology, systems physiology; Science: Physiology