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Abstract Objective High-altitude chronic hypoxia can alter the immune status, yet the immune regulatory characteristics of various vaccine adjuvants in this environment remain to be fully elucidated. Accordingly, emph...

Abstract Background Tooth avulsion, a severe dental trauma prevalent among adolescents, is commonly treated with delayed replantation. However, this procedure is frequently complicated by root resorption, which can ultim...

IntroductionChronic spontaneous urticaria (CSU) is a clinical diagnosis managed according to American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) guide...

Abstract Background Collagenous fibroma (CF), also known as desmoplastic fibroblastoma, is a rare benign fibroblastic/myofibroblastic tumor characterized by FOSL1/FOS rearrangements. CF typically presents as a solitary, ...

ABSTRACT Background and Aims Late diagnosis of chronic hepatitis B and C, often identified by the presence of advanced disease such as hepatocellular carcinoma or decompensated cirrhosis at the time of initial hepatitis ...

A 38-year-old woman was admitted to the Department of Dermatology due to purple-pinkish macules observed on the thighs and buttocks, which were very firm on palpation. There were also several white-silverish papules on ...

Chronic kidney disease has become a global pandemic, with its burden felt mostly in developing countries where there is a deficiency or outright lack of policy and funding for chronic kidney disease prevention and treatm...

Carla S Enriquez,1– 3 Alka Bishnoi,1 Musola N Oniyide,4 Katherine L Jennings,1 Roger Luo5,6 1Department of Physical Therapy, Kean University, Union, NJ, USA; 2Department of Physical Medicine and Rehabilitation, Johns H...

BackgroundThe adverse impacts of chronic pain extend far beyond the physical sensation itself. Chronic pain, an age-related condition, exacerbates geriatric disease burden and drives a central sensitivity-neuropsychiatri...

Chronic generalized periodontitis (CGP) is a widespread inflammatory and destructive disease of periodontal tissues that leads to progressive destruction of supporting structures of the teeth and tooth loss. One of the k...

ObjectiveTo develop a Health Action Process Approach (HAPA) based exercise rehabilitation program for chronic heart failure (CHF) patients and evaluate its effectiveness.MethodsA randomized controlled trial was carried o...

BackgroundHeart failure (HF) with chronic arrhythmias is associated with autonomic dysfunction and poor outcomes. Heart rate variability (HRV) reflects autonomic dysfunction and predicts outcomes in HF. This study invest...

Ying Zhao, Jingjing Zhang, Wei Qian, Hailing Mu, Qiushuang Tang, Peng Zhang Department of Anesthesiology, The Second People’s Hospital, Wuhu, Anhui, People’s Republic of ChinaCorrespondence: Peng Zhang, Department of...

Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...

Abstract Background Chronic endometritis (CE) has two principal subtypes—non-specific chronic endometritis (NSCE) and endometrial tuberculosis (ETB). Both can adversely affect embryo implantation. Although ETB is gener...

Environmental factors such as air pollution, weather events, and ambient toxins are major contributors to human disease, with disproportionate impacts on vulnerable populations. In Puerto Rico, chronic exposure to air po...

Abstract Background Gait impairments following chronic neurological conditions, such as spinal cord injury (SCI), represent a major challenge for rehabilitation, with limited options to sustain functional recovery and pa...

Chronic illness is associated with lower quality of life, yet it remains unclear whether this association differs by employment arrangements, particularly gig work. Using longitudinal data (2019–2024) from a nationally...

Abstract Aims/Introduction Diabetes mellitus significantly contributes to renal complications, especially in patients with coronary artery disease (CAD). Effective glycemic control is important; however, the ideal hemogl...

Abstract Background Chronic obstructive pulmonary disease (COPD) significantly affects the quality of life of older adults. The growing impact of this chronic condition poses significant challenges for healthcare systems...

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe, life-threatening complication of pulmonary embolism with pulmonary hypertension (PH). The combination of insufficient resolution of thrombi following pul...

Background: Neck pain is a common musculoskeletal disorder frequently associated with proprioceptive impairments and reduced cervical mobility. This study aimed to evaluate the immediate effects of Mulligan’s mobilizat...

Abstract Background As the incidence of ATR is increasing the risk of ruptures being missed escalates and more injuries are suspected to become chronic. This study aimed to assess the incidence and causes of delayed diag...

ObjectiveTo examine the heterogeneity and determinants of Traditional Chinese Medicine Health Literacy (TCM-HL) among middle-aged and older adults patients with chronic diseases and its association with disease burden an...