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BackgroundGranular cell astrocytoma (GCA) is a rare, morphologically distinct variant of IDH-wildtype glioblastoma that can appear deceptively low-grade yet behave aggressively. Its molecular features remain poorly defin...

ABSTRACT: Objectives: To evaluate and synthesise the current evidence on the efficacy of laser-activated irrigation in endodontics, with a focus on microbial reduction, postoperative outcomes, and its potential as an ad...

Malignant solid tumors of the gastrointestinal tract are clinically rare in children, with malignant solid tumors of the esophagus being particularly uncommon. Clinical reports on esophageal cancer in children are extrem...

IntroductionBone-seeking radiopharmaceuticals are the treatment of choice with clinical benefits for patients with extensive skeletal metastases, but they can also cause serious radiation-related adverse events (rrAEs). ...

Weiya Zhuang,1 Daozhe Lin,2 Chengliang Chen2 1Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, People’s Republic of China; 2Department of Thyroid an...

Two adult domestic shorthair cats were evaluated for progressive neurologic deficits caused by spinal cord compression secondary to vertebral osteosarcoma, giant-cell subtype. Feline giant cell osteosarcoma represents a ...

BackgroundPrimary atopic disorders (PADs) are monogenic inborn errors of immunity marked by severe allergic disease. Heterozygous gain-of-function (GOF) variants in STAT6 have recently been recognized as a PAD associated...

Danhua Guo,1,2 Shuqiong He,1,2 Na Lin,1,2 Yifang Dai,1,2 Ying Li,1,2 Liangpu Xu,1– 3 Xiaoqing Wu1– 4 1Department of Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital College of ...

Introduction: Infections caused by vector-borne pathogens and zoonotic agents are a great economic burden in developing countries like India because their numbers keep increasing every year. National programs like the Na...

Purpose: The study aimed to determine the clinical features of the eye trauma and its outcomes in children in Ukraine. Methods: The features of the clinical picture of different types of eye trauma, methods of treatment ...

Abstract Background Subtalar arthroereisis (STA) is a commonly used surgical approach for treating pediatric flatfoot. It remains unclear whether STA combined with spring ligament repair surgery is necessary. The purpose...

Abstract Background As cases of neurosyphilis are rising worldwide – especially in people living with HIV (PLWH) – current data on clinical presentation, diagnostics and management of neurosyphilis in Europe are of h...

Abstract Introduction and objectives Perindopril-induced thrombocytopenia is a rare but potentially serious adverse drug reaction. It remains underrecognized in clinical practice, particularly in elderly patients with ca...

Introduction: Online Gambling Disorder is an increasingly prevalent behavioral addiction frequently accompanied by depressive symptoms and significant functional impairments. Despite growing clinical recognition, pharmac...

Abstract Background The NHS has introduced a range of new and extended roles in recent decades. Physician associates / assistants (PAs) have become one of the most politically scrutinised of these roles. In 2024, the UK ...

Introduction: Malingering, the intentional fabrication or exaggeration of symptoms for external gain, remains a significant challenge in forensic psychiatry. Psychiatric illnesses are particularly vulnerable to malingeri...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Background: This study aims to evaluate the effectiveness and efficiency of combined multiple-case teaching (MCT) and narrative medicine teaching (NMT) method compared with lecture-based learning (LBL) in the clinical pr...

Abstract Background and Objectives pediatric Cardiopulmonary resuscitation (CPR) is critical for saving children who experience cardiac arrest, but traditional teaching is often ineffective at improving clinical competen...

Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal storage metabolic disorder caused by pathogenic mutations in the iduronate-2-sulfatase (IDS) gene. Herein, we report the case of a 2-year-old male...

Abstract Background Regulatory barriers present significant challenges to clinical trial approval during both “peacetime” and pandemics, particularly for multi-country clinical trials sponsored by academic institutio...

Abstract Background Bordetella pertussis (BP) infection has risen rapidly in pediatrics recently, and next-generation sequencing has significantly improved pertussis’ early diagnosis. High detection rates raise the con...

Abstract Circumaortic left renal vein (CLRV) is a rare variation in which two renal veins encircle the aorta prior to draining into the inferior vena cava (IVC) and can be classified into three types based on branching p...

Abstract Objective: Cushing’s syndrome, characterized by chronic hypercortisolism, is associated with various health risks, including psychiatric symptoms and cognitive impairments. This systematic review of case stud...