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Materias / palabras clave: autoimmunity, hypersensitivity, allergy, tumor immunology, immunodeficiencies, vaccine; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

IntroductionIndividuals with inborn errors of immunity (IEI) are increasingly reaching reproductive age, yet guidance on fertility preservation, genetic counseling, medication adjustments in pregnancy and breastfeeding, ...

Materias / palabras clave: allergy, asthma, immunology, clinical trials, population studies, regional research; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

ObjectiveTo investigate the clinical features and serological characteristics of patients with primary Sjögren's syndrome (pSS) complicated with sensorimotor neuropathy (SMN), and to provide a reference for the clinical...

BackgroundInfantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its progression. The HMGB1-TLR4 signaling pathway, a ...

The therapeutic efficacy of Mesenchymal Stromal Cells (MSCs) has been demonstrated in a multitude of pre-clinical studies and clinical trials, yet the translation of MSC therapies is limited by biological factors such as...

Abstract Background Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking. Objectives Identify clinicopathologic features that differentiate pITP fro...

BackgroundThe toxicities associated with immune checkpoint inhibitors (ICIs) can affect nearly all organ systems. Although previous studies have examined specific types of immune-related adverse events (irAEs) associated...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...

Sepsis remains a major challenge in critical care medicine worldwide, characterized by a dynamic imbalance of the immune system between two extremes: “immunoparalysis” and “hyperactivation.” This dysregulation se...

IntroductionPediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early cognitive and psychosocial impact, and difficulties with long-term treatment adherence. T...

ObjectiveThis review summarizes the current evidence on the impact of isolated antiphospholipid antibody positivity (IAAP) on pregnancy outcomes. It analyzes risk differentials across antibody subtypes, synthesizes the u...

IntroductionSjögren’s disease (SjD) is a chronic autoimmune disorder characterized by dry mouth (xerostomia) and dry eyes (xerophthalmia) due to inflammation in exocrine glands, particularly the salivary and lacrimal ...

This mini-review aims to examine how molecular PET and immuno-PET may complement tissue-based biomarkers in gastric cancer immunotherapy by enabling whole-body assessment of target expression, stromal biology, immune eff...

Psoriasis is a common chronic inflammatory skin disorder frequently accompanied by multisystem involvement, with increasing concern regarding its association with renal impairment. The advent and widespread use of biolog...

IntroductionSalmonella enterica serovars Typhi and Paratyphi A cause millions of cases and thousands of deaths annually, predominantly affecting children in South and Southeast Asia. Following the licensure and World Hea...

The article is devoted to reviewing the main methods of practice-oriented teaching of medical students at the Department of Internal Medicine No. 1, Clinical Immunology and Allergology named after Academician Y. M. Neyko...

Caring for kidney transplant recipients (KTRs) requires specialized knowledge in areas as varied as nephrology, immunology, pharmacology, endocrinology, infectious disease, and cardiology. In this context of increasing c...

Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), has killed nearly one billion people in the last two centuries. Nowadays, TB remains a major global health problem, ranking among the thirteen l...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

ABSTRACT Background Donkeys are routinely vaccinated with protocols developed for horses, yet species‐specific data on their immune responses are limited. Hypothesis/Objectives We hypothesized that donkeys exhibit robu...

Abstract Case Description We describe a case of presumptive acquired systemic lupus erythematosus secondary to phenobarbital administration in a dog, which resolved with withdrawal of the drug. Clinical Findings A 3.5 ...

Abstract Background Copper (Cu), zinc (Zn), and the copper/zinc ratio (Cu/Zn), which have been studied in gastrointestinal disorders of humans, may facilitate disease prognosis. Objective Evaluate the predictive potentia...