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Background Clinical brain–computer interface (BCI) for mental disorders is an emerging interdisciplinary research field, posing new ethical concerns and challenges, yet lacking practical ethical governance guidelines f...

Materias / palabras clave: medical research, dental research, veterinary research, biological science research; Medicine

ABSTRACT Background and Aims The involvement of clinical nurses in the utilization of nursing research in practice has been reported to be minimal. Globally, several studies have reported a host of challenges that hinder...

Background: Adjustment disorder (AjD) is a significant yet often underdiagnosed condition in workplace mental health. The International Adjustment Disorder Questionnaire (IADQ) has shown promise as a screening tool, but...

Coronary artery ectasia (CAE) is a vascular lesion characterized by abnormal dilation of the coronary arteries, with complex pathogenesis and diverse clinical manifestations. CAE can be classified into primary and second...

ABSTRACT: Objectives: To evaluate and synthesise the current evidence on the efficacy of laser-activated irrigation in endodontics, with a focus on microbial reduction, postoperative outcomes, and its potential as an ad...

ObjectiveApproximately half of common variable immunodeficiency (CVID) patients develop debilitating and life-threatening clinical manifestations of immune dysregulation, including lymphoproliferation, cytopenias, inters...

Introduction: Gestational diabetes affects 5-25% of pregnancies, while pre-gestational diabetes complicates 1-2% of all pregnancies. Women with any form of diabetes during pregnancy have higher rates of maternal and peri...

Abstract Background Dogs with immune‐mediated disease often receive glucocorticoids with clopidogrel, but ulcerogenic effects of current protocols are unknown. Hypothesis/Objectives To compare gastrointestinal endoscop...

This study aimed to investigate the clinical significance of bee venom pharmacopuncture in patients with Bell’s palsy by synthesizing evidence from several comparative clinical studies. A narrative review was conduct...

Introduction: Neonatal Conjugated Hyperbilirubinaemia (CHB) poses a significant diagnostic challenge in day to day practice because of its varied aetiologies with non-specific clinical presentations. The rationale of the...

Abstract Background As cases of neurosyphilis are rising worldwide – especially in people living with HIV (PLWH) – current data on clinical presentation, diagnostics and management of neurosyphilis in Europe are of h...

Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...

Successful completion of industry-sponsored clinical trials requires effective collaboration between sponsors and clinical research sites recruiting patients. As pharmaceutical companies specialize in more therapy areas,...

Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...

Maria Hee Jung Park Frausing,1– 3 Morten Schmidt,2,4 Ole Dan Jørgensen,5,6 Frederikke Nørregaard Jakobsen,7 Frederik Mikkelsen,1,2 Jacob Moesgaard Larsen,8 Charlotte Ellen Larroudé,9 Berit Thornvig Philbert,10 Jens ...

Abstract Background and objectives The under-representation of vulnerable groups in clinical trials, including persons with disabilities, could affect the applicability of trial findings to real-world public health inter...

Pregnant women, particularly those in the first trimester, have been historically excluded from clinical trials, resulting in substantial evidence gaps for the prevention and treatment of malaria in early pregnancy. Desp...

Abstract Background Regulatory barriers present significant challenges to clinical trial approval during both “peacetime” and pandemics, particularly for multi-country clinical trials sponsored by academic institutio...

Medicarpin (MED) is an isoflavonoid compound derived from traditional Chinese medicine (TCM). Numerous preliminary experimental studies have shown that MED has significant pharmacological effects in the treatment of canc...

Sepsis remains a major challenge in critical care medicine worldwide, characterized by a dynamic imbalance of the immune system between two extremes: “immunoparalysis” and “hyperactivation.” This dysregulation se...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...

Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultim...