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117 resultados encontrados.

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Clinical Trial of Bawang Dayak Leaves Capsules (Eleutherine americana) in Active Smokers
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Clinical Trial of Bawang Dayak Leaves Capsules (Eleutherine americana) in Active Smokers
Sri Wahdaningsih et al · Universitas Gadjah Mada · 2024 · ISSN 1410-5918
Smoking is an unhealthy behavior, particularly for the respiratory system's health due to the free radicals found in cigarette smoke. Eleutherine americana or Bawang Dayak has antioxidant properties which can neutralize ...
LCC LCC:MedicineIdioma eng
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A potential impact of artificial intelligence on pharmaceutical drug design and clinical trials
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A potential impact of artificial intelligence on pharmaceutical drug design and clinical trials
Muhammad Naeem Aamir et al · AMMANIF · 2025 · ISSN 2521-0521
Pharmaceutical technology has increasingly integrated artificial intelligence (AI) in recent years. This technology offers significant benefits, including saving time and money while enhancing the understanding of the re...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Trial watch: antibody-drug conjugates in cancer therapy
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Trial watch: antibody-drug conjugates in cancer therapy
Flora Doffe et al · Taylor & Francis Group · 2026 · ISSN 2162-402X
Antibody-drug conjugates (ADCs) combine the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads. In recent years ADCs have emerged as a clinically validated component of mode...
LCC LCC:Immunologic diseases. Allergy; TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbIdioma eng
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A randomized crossover clinical trial comparing 24-h blood pressure measurements from two different cuffless wrist ambulatory monitors with cuffed ambulatory monitoring for translation to clinical practice: Rationale and Design of Continuum BP study
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A randomized crossover clinical trial comparing 24-h blood pressure measurements from two different cuffless wrist ambulatory monitors with cuffed ambulatory monitoring for translation to clinical practice: Rationale and Design of Continuum BP study
Ajay K. Gupta et al · Elsevier · 2026 · ISSN 2666-6022
Study objective: Cuffless blood pressure (BP) measuring devices have potential to improve screening, diagnosis and management of hypertension. However, translation of BP estimates from such devices to cuffed BP readings,...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBjaXJjdWxhdG9yeSAoQ2FyZGlvdmFzY3VsYXIpIHN5c3RlbQ~~Idioma eng
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Optimal auxiliary-covariate-based two-phase sampling design for semiparametric efficient estimation of a mean or mean difference, with application to clinical trials
Artículo
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Optimal auxiliary-covariate-based two-phase sampling design for semiparametric efficient estimation of a mean or mean difference, with application to clinical trials
Gilbert, Peter B. et al · John Wiley & Sons Ltd · 2014 · ISSN 0277-6715
To address the objective in a clinical trial to estimate the mean or mean difference of an expensive endpoint Y, one approach employs a two-phase sampling design, wherein inexpensive auxiliary variables W predictive of Y...
Idioma eng
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Navigating the Next Wave of Clinical Trials for Alzheimer’s Disease Research
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Navigating the Next Wave of Clinical Trials for Alzheimer’s Disease Research
Rachel Sudhakar · University of Ottawa · 2026 · ISSN 2292-650X
Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...
LCC LCC:Medicine; TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
Yi Sun et al · BMC · 2026 · ISSN 1757-6512
Abstract Background Acute liver failure (ALF) is a life-threatening syndrome characterized by rapid deterioration of liver function, resulting in high mortality and posing a substantial global health burden. Human embryo...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOkJpb2NoZW1pc3RyeQ~~Idioma eng
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Harmonizing interactions between clinical trial sponsors and study research sites: An appraisal of the key challenges and recommendations for addressing them
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Harmonizing interactions between clinical trial sponsors and study research sites: An appraisal of the key challenges and recommendations for addressing them
Kesley Holmes et al · Cambridge University Press · 2026 · ISSN 2059-8661
Successful completion of industry-sponsored clinical trials requires effective collaboration between sponsors and clinical research sites recruiting patients. As pharmaceutical companies specialize in more therapy areas,...
LCC LCC:MedicineIdioma eng
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A technology‐enabled service for perinatal collaborative care models: A randomized clinical trial
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A technology‐enabled service for perinatal collaborative care models: A randomized clinical trial
Emily S. Miller et al · Wiley · 2026 · ISSN 2997-9684
Abstract Introduction Perinatal mental health conditions are common yet frequently undertreated. Perinatal collaborative care models improve access to evidence‐based care but face implementation challenges related to w...
LCC LCC:Biology (General); LCC:Internal medicine; TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Can anxiety in undergraduate students in a high-fidelity clinical simulation be predicted? : A randomized, sham-controlled, blinded trial
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Can anxiety in undergraduate students in a high-fidelity clinical simulation be predicted? : A randomized, sham-controlled, blinded trial
Martín Rodríguez, Francisco et al · Churchill Livingstone · 2021 · ISSN 0260-6917
Introduction: High-fidelity clinical simulation has implied a revolution in health science training. Despite its benefits, some drawbacks could hinder the learning process, especially the anxiety produced during such sce...
Idioma eng
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Development of a Patient Decision Aid for the DAHANCA 35 Proton Radiotherapy Trial: An Iterative Development Process with User-Centered Design Elements
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Development of a Patient Decision Aid for the DAHANCA 35 Proton Radiotherapy Trial: An Iterative Development Process with User-Centered Design Elements
Anne Wilhøft Kristensen et al · SAGE Publishing · 2026 · ISSN 2381-4683
Background. Deciding whether to participate in a radiotherapy trial is complex for patients with head and neck cancer. Standard patient information leaflets meet ethical requirements but do not provide balanced compariso...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Effect of multicomponent exercise intervention on older adults with mild cognitive impairment based on HAPA-TPB theory (MIND-STEP): trial design and baseline data for a randomized controlled trial
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Effect of multicomponent exercise intervention on older adults with mild cognitive impairment based on HAPA-TPB theory (MIND-STEP): trial design and baseline data for a randomized controlled trial
Na Zhang et al · BMC · 2026 · ISSN 1745-6215
Abstract Background Physical exercise has emerged as a promising non-pharmacological approach for improving cognitive and physical function in older adults with mild cognitive impairment (MCI). However, most existing int...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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The effect of appendectomy on the clinical course of ulcerative colitis: a synopsis of the ACCURE randomised controlled trial
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The effect of appendectomy on the clinical course of ulcerative colitis: a synopsis of the ACCURE randomised controlled trial
NIHR Journals Library · 2026 · ISSN 2050-4373
Background Chronic relapsing diseases, such as ulcerative colitis, incur considerable long-term health burden to the patient and the state. Early interventions that reduce the rate of relapse could provide considerable b...
LCC LCC:MedicineIdioma eng
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A scoping review of randomized controlled trials in the early phase of the COVID-19 pandemic: country-level research response to COVID-19 therapeutics and vaccines
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A scoping review of randomized controlled trials in the early phase of the COVID-19 pandemic: country-level research response to COVID-19 therapeutics and vaccines
Hiroki Saito et al · BMC · 2026 · ISSN 1471-2334
Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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De-escalation of adjuvant radio(chemo)therapy for patients with HPV-positive head and neck squamous cell carcinoma: study protocol for a phase I trial to reduce late toxicity (DELPHI)
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De-escalation of adjuvant radio(chemo)therapy for patients with HPV-positive head and neck squamous cell carcinoma: study protocol for a phase I trial to reduce late toxicity (DELPHI)
Annett Linge et al · BMC · 2026 · ISSN 1471-2407
Abstract Background Patients with locally advanced head and neck squamous cell carcinoma are receiving adjuvant radio(chemo)therapy as standard of care, according to national guidelines. However, patients with human papi...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Elucidating the phase 1 trial experience among study participants following completion of the INTERCEPT-AD study of sabirnetug (ACU193) for early Alzheimer’s disease: a qualitative interview study
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Elucidating the phase 1 trial experience among study participants following completion of the INTERCEPT-AD study of sabirnetug (ACU193) for early Alzheimer’s disease: a qualitative interview study
Elizabeth Merikle et al · BMC · 2026 · ISSN 1745-6215
Abstract Background Recruitment and retention remain persistent challenges in Alzheimer’s disease (AD) clinical trials, particularly as studies increasingly focus on earlier disease stages and require longer participat...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Equity and representation in oncology clinical evidence for FDA-approved treatments and the impact of COVID-19
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Equity and representation in oncology clinical evidence for FDA-approved treatments and the impact of COVID-19
Hao Cheng et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Immersive virtual reality for reducing public speaking anxiety in students accessing a university psychological counseling service: protocol for a randomized controlled trial
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Immersive virtual reality for reducing public speaking anxiety in students accessing a university psychological counseling service: protocol for a randomized controlled trial
Gianluca Mariano Colella et al · BMC · 2026 · ISSN 2050-7283
Abstract Background Public Speaking Anxiety (PSA) is a form of social anxiety spread among university students, negatively affecting both academic performance and overall psychological well-being. Virtual Reality (VR)–...
LCC TENDOlBzeWNob2xvZ3k~Idioma eng
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Mesenchymal stem/stromal cell-based therapies for autism spectrum disorder: emerging evidence and clinical prospects
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Mesenchymal stem/stromal cell-based therapies for autism spectrum disorder: emerging evidence and clinical prospects
Minghui Xu et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...
LCC LCC:MedicineIdioma eng
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Comparative evaluation of Bayesian external information borrowing and frequentist approaches in underpowered confirmatory trials
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Comparative evaluation of Bayesian external information borrowing and frequentist approaches in underpowered confirmatory trials
Ruobing Li et al · BMC · 2026 · ISSN 1471-2288
Abstract The application of Bayesian statistics in pivotal clinical trials has gained increasing attention, particularly for underpowered confirmatory trials such as those in pediatric and rare disease populations. Bayes...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Efficacy and safety of Ruyi Zhenbao tablet in patients with lumbar disc herniation: A protocol for a multicenter, randomized, positive-controlled trial
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Efficacy and safety of Ruyi Zhenbao tablet in patients with lumbar disc herniation: A protocol for a multicenter, randomized, positive-controlled trial
Zhiqiang Li et al · Elsevier · 2026 · ISSN 2095-7548
Objective: To evaluate the efficacy and safety of Ruyi Zhenbao tablet (RYZBT), a traditional Tibetan medicinal formula, for the treatment of lumbar disc herniation (LDH), that is frequently associated with lower back pai...
LCC TENDOk1pc2NlbGxhbmVvdXMgc3lzdGVtcyBhbmQgdHJlYXRtZW50cw~~Idioma eng
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Evaluation of randomized controlled trial literature in traditional Chinese medicine: a literature quality assessment system
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Evaluation of randomized controlled trial literature in traditional Chinese medicine: a literature quality assessment system
Yunan Zhang et al · BMC · 2026 · ISSN 1745-6215
Abstract Background Previous studies have evaluated traditional Chinese medicine (TCM) clinical randomized controlled trial (RCT) literature broadly, but they have provided limited depth in evaluating the specific aspect...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Mindful self-compassion to reduce stigma among individuals diagnosed with lung cancer (MSC-LC): a pilot study protocol for a parallel-group, randomized controlled trial
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Mindful self-compassion to reduce stigma among individuals diagnosed with lung cancer (MSC-LC): a pilot study protocol for a parallel-group, randomized controlled trial
Timothy J. Williamson et al · BMC · 2026 · ISSN 2055-5784
Abstract Background Lung cancer stigma (i.e., perceived and internalized negative appraisal and devaluation associated with lung cancer) is a clinically significant psychosocial concern among individuals diagnosed with l...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Personalized embryo transfer guided by endometrial receptivity analysis: a systematic review with meta-analysis
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Personalized embryo transfer guided by endometrial receptivity analysis: a systematic review with meta-analysis
Glujovsky, D. et al · Oxford University Press · 2023 · ISSN 1305-1317
STUDY QUESTION: Does a personalized embryo transfer (pET) guided by tests for endometrial receptivity (TER) increase the effectiveness of ART procedures? SUMMARY ANSWER: The use of TER-guided pET is not supported by curr...
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