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IntroductionWhilst individually rare, affecting only a small percentage of the population, rare diseases as a whole impact around 6% of the global population (with this number likely an underestimate). Rare diseases are ...

Abstract Objective Sickle cell anemia (SCA) is associated with substantial end‑organ morbidity, yet the circulating microRNA (miRNA) landscape in clinically stable, comorbidity‑free adults with SCA is poorly defined....

Background Patients who suffer comorbidity of major depressive disorder (MDD) and chronic pain (CP) maintain a complex interplay between maladaptive prospective memory (PM) and retrospective memory (RM) with physical pai...

Abstract Background Lung stereotactic body radiotherapy (SBRT) is the standard of care for patients with inoperable early-stage non-small cell lung cancer (NSCLC), who frequently have significant comorbidities. There is ...

Materias / palabras clave: Medicine

Materias / palabras clave: Medicine

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Materias / palabras clave: comorbidity, multimorbidity, multiple chronic conditions; Medicine

Materias / palabras clave: multimorbidity, comorbidity, multiple chronic conditions; Medicine

INTRODUCTION: The objective of this study is to evaluate the clinical parameters that affect mortality in patients diagnosed with COVD-19. We examined the following variables: Reverse transcription polymerase chain react...

Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...

Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...

Aims: Preoperative education is routinely integrated into enhanced recovery pathways for hip and knee arthroplasty, yet its independent effect on early outcomes remains uncertain. This study examined whether completion o...

Abstract Background China bears a high burden of both hepatitis B virus (HBV) infection and type 2 diabetes mellitus (T2DM). T2DM accelerates the progression of liver disease among individuals infected with HBV. This stu...

Abstract Objective: The aim of this study was to determine which individual characteristics of smokers are associated with their adherence to a support group for smoking cessation. Methods: Smokers from Porto Alegre, B...

BackgroundCoronary heart disease (CHD) frequently coexists with diabetes mellitus (DM), resulting in a complex metabolic–vascular disorder with poor cardiovascular prognosis. Oral Chinese patent medicines (OCPMs) are w...

Abstract Background Intertrochanteric femoral fractures are common in the elderly population and are associated with substantial mortality. While fracture reduction quality is known to influence mechanical outcomes, its ...

Abstract Objective To explore and describe sociodemographic characteristics, crack consumption patterns, and psychiatric comorbidities of female crack users receiving treatment at therapeutic communities. Methods Thi...

Abstract Introduction We describe the burden of severe influenza in England overall, and in risk groups (as defined by age, immunocompromise, and other comorbidities) and those with recent COVID-19. Methods The INFORM (I...

Abstract Backgrounds Malnutrition is common among hospitalised older adults, and weight may continue to decline after discharge without nutritional support. Post-discharge home visit programmes by dieticians show positiv...

Abstract Osteoporotic fractures (OPF) and hypertension frequently co-occur in older adults, yet comprehensive datasets integrating clinical, pharmacological, and longitudinal outcome data remain scarce. We describe a lon...

Abstract Objective Streptococcus agalactiae is an important pathogen in neonates and pregnant women. Neonatal invasive infections due to S. agalactiae are life-threatening and preventive strategies for this challenge o...

Abstract Objective To examine whether long-term opioid use after total knee arthroplasty (TKA) is associated with subsequent risks of major adverse cardiovascular events (MACE) and all-cause mortality in patients with kn...