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Abstract Background Uveal melanoma (UM) is a rare disease, but the most common intraocular malignancy in adults, with incidence rates in Europe ranging from 1.3 to 8.6 cases per million annually. Although local tumor con...

This study examined teachers’ pedagogical strategies for adapting non-indigenous and indigenous species in teaching the classification of living things in Biology. The research was guided by connectivism learning theor...

Abstract Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organs/tissues in metabolism and inflammation, yet little is known about the contribution of liver and marrow adipose tissu...

The complement system is a blood-based immune network that plays a crucial role in fighting infection and maintaining immune homeostasis. The membrane attack complex (MAC) is a pore assembled from complement proteins tha...

Complement activation significantly contributes to the progression of diabetic kidney disease (DKD). Recent studies have shown that renal levels of the complement component 3 (C3) and its receptor (C3aR) increase with di...

ABSTRACT Cells rely on surface receptors to sense and initiate signalling cascades essential for numerous cellular processes, but engineering of synthetic genetic circuits to sense and rewire receptor activities for user...

Midlife represents a biological “phenotype transition” for women, during which sarcopenic obesity risk can rise despite stable BMI. Evidence anchored to the STRAW + 10 framework suggests that the interval surroundi...

Understanding the nutritional physiology of mosquito larvae is crucial for optimizing massrearing practices and improving control strategies. Here we combined complementary opticaland spectroscopic techniques, including ...

This mini-review aims to examine how molecular PET and immuno-PET may complement tissue-based biomarkers in gastric cancer immunotherapy by enabling whole-body assessment of target expression, stromal biology, immune eff...

Abstract Background Radiomics analysis of 18F-FDG PET/CT enables extraction of high-dimensional quantitative features that may serve as imaging biomarkers for tumor biology. In particular, in non-small cell lung cancer (...

Graph-based pangenome references often misrepresent Copy Number Variations (CNVs) and Variable Number Tandem Repeats (VNTRs) as alternative acyclic paths, which hinders downstream analyses, degrades alignment behavior, a...

Mitochondria orchestrate energy conversion and cell fate, yet label-free approaches that report both functional and physical states at the single-organelle level are nonexistent. Here, we combine atomic force microscopy ...

Carabids are important natural biocontrol agents for pest regulation in agricultural landscapes. Their role in the ecosystem is related to functional traits, which are themselves filtered by both the degree of habitat di...

Abstract Transmissible spongiform encephalopathies, or prion diseases, are fatal neurodegenerative diseases that are medically, economically, and ecologically important. In livestock and wildlife, detection to prevent in...

Abstract The precise separation of chromosomes during meiosis is critical for maintaining genetic stability, a process intricately orchestrated by Shugoshin (SGO) proteins. SGO plays a pivotal role in protecting the cent...

Abstract Background Induced mutation through physical mutagens, such as gamma irradiation is an effective and complementary breeding tool to enhance crop improvement by increasing genetic variation and creating heritable...

BackgroundIntegrated single-cell morpho-molecular analysis is vital for precision pathology, yet accurate nuclear instance segmentation from standard histopathology images remains challenging due to staining variability ...

This data paper describes bacterial and fungal communities associated with the sponge Chondrilla nucula collected from two Eastern Mediterranean populations (North and South Aegean Sea) and maintained under controlled co...

Abstract Background Terpenes and phenolic compounds are multifunctional plant metabolites that contribute to defense, signaling, and ecological interactions, while supporting industrial applications. Here, we implemented...

Abstract Background Rapid and accurate pest diagnosis is essential for reducing crop losses and improving agricultural productivity. Most existing methods rely on deep learning-based object detection to classify pests in...