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IntroductionVirtual control groups (VCGs) are proposed as a means to reduce reliance on live animals in preclinical toxicology studies. Despite the potential benefits of VCGs, concerns remain regarding their comparabilit...

Introduction: Patellofemoral Pain Syndrome (PFPS) is one of the most common causes of anterior knee pain, yet its radiographic diagnostic indicators remain poorly defined. Aim: To evaluate morphometric parameters, inc...

Abstract Vitamin D deficiency has been associated with a range of neurological and allergic conditions. Whether such an association exists in multiple chemical sensitivity (MCS) has not been clarified. This study aimed t...

PURPOSE: The study compared Resting Heart Rate Variability (HRV) in elderly women practicing Tai Chi Chuan (TCC) versus non-exercising controls to evaluate its impact on heart autonomic modulation. METHODOLOGY: Twenty el...

Understanding how socioeconomic development modulates trait–environment linkages in the Anthropocene, particularly its mechanistic role in reshaping the relative importance of climate versus soil drivers, remains poorl...

PURPOSE: The study compared Resting Heart Rate Variability (HRV) in elderly women practicing Tai Chi Chuan (TCC) versus non-exercising controls to evaluate its impact on heart autonomic modulation. METHODOLOGY: Twenty el...

Introduction and Aims: Mandibular movement is a complex physiological process essential for orofacial function. Patients with disc displacement without reduction (DDWoR) exhibit significant kinematic impairments, which a...

IntroductionLipedema, a painful disease that almost exclusively affects women, leads to an excessive accumulation of subcutaneous adipose tissue, primarily in the extremities. Morphologically, it is characterized by hype...

Abstract Background Identification of disease-associated spectral alterations of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is critical to improving patient outcomes. Protein stru...

IntroductionFamilial partial lipodystrophy (FPL) is a rare condition related to partial deficiency of adipose tissue and consequent insulin resistance resulting in metabolic alterations. Although type 2 diabetes mellitus...

ABSTRACT Background and Aims Limited evidence suggests autoimmune thyroiditis (AT) could represent a risk factor for cervical artery dissection (CeAD). We tested the hypothesis of a positive association between AT and Ce...

ABSTRACT Background and Objectives Systemic inflammation indices derived from complete blood counts (CBC) are accessible markers of inflammatory burden, but their relationship with circulating cytokines in psoriasis rema...

Background: The relationship between vitamin D receptor gene variations and other risk factors in pulmonary tuberculosis remains unclear, largely due to the complex interplay of genetic and environmental factors. The pur...

ABSTRACT Background and Aims Falls pose a significant public health risk for community‐dwelling stroke survivors. Current research on biomechanical parameters to trip perturbation in standing tasks often fails to predi...

Abstract Animal responses to fear cues are shaped by competing motivations such as hunger, access to mates and safety. In our previous work, wild mice (Apodemus spp.) showed little reaction to non-native predator scents....

RationaleInborn errors of immunity (IEIs) predispose individuals to recurrent respiratory infections and immune dysregulation, which together can drive inflammatory lung complications, including interstitial lung disease...

Abstract Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms. While i...

BackgroundInfantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its progression. The HMGB1-TLR4 signaling pathway, a ...

Abstract Background Early detection of renal involvement in ANCA-associated vasculitis (AAV) is crucial, as functional changes often precede anatomical damage. Current diagnostic standards, such as the measurement of ser...

# Background The countermovement jump (CMJ) is commonly used to assess neuromuscular performance in athletic populations; however, force plate–derived mechanical metrics may not fully reflect central nervous system (CN...

Abstract Background Sudden Infant Death Syndrome (SIDS) remains a leading cause of infant mortality worldwide, yet its underlying mechanisms are largely unknown. SIDS etiology is complex and involves the interplay betwee...

Abstract Background Ischemic stroke (IS) remains a leading cause of death and disability worldwide. Stroke–heart syndrome, triggered by acute cerebral ischemia, causes autonomic dysfunction that can result in myocardia...

Abstract Objective Sickle cell anemia (SCA) is associated with substantial end‑organ morbidity, yet the circulating microRNA (miRNA) landscape in clinically stable, comorbidity‑free adults with SCA is poorly defined....

Background: Type 2 diabetes mellitus (T2DM) involves metabolic disturbances and endothelial dysfunction, raising cardiovascular risk. Objective: To compare the effects of 8 weeks of resistance, endurance, and combined ex...