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ObjectiveHigh-risk localized prostate cancer is often associated with a higher risk of disease progression post-surgery. While radical prostatectomy (RP) is a cornerstone treatment, neoadjuvant chemohormonal therapy (CHT...

Abstract Objectives Gastroesophageal reflux disease (GERD) is estimated to affect up to one-quarter of the Italian population, generating immense treatment costs. An emergent surgical treatment involving implantation of ...

Background International evidence suggests that Early Intervention for Psychosis (EIP) services are both effective and cost-effective. Such evidence, however, comes almost exclusively from high-income countries. Aims O...

Abstract Background Non-invasive prenatal testing (NIPT) has emerged as a highly accurate screening modality for fetal aneuploidies. However, its cost-effectiveness in resource-constrained settings remains unclear. This ...

Objective This study aims to evaluate the cost-effectiveness of latent tuberculosis infection (LTBI) screening strategies using interferon-gamma release assays (IGRAs) among migrants, integrating social vulnerability and...

Abstract Objective To evaluate the cost-effectiveness of zanubrutinib compared to ibrutinib in the first-line treatment of chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma (SLL) from the perspective of the...

BackgroundThe adverse impacts of chronic pain extend far beyond the physical sensation itself. Chronic pain, an age-related condition, exacerbates geriatric disease burden and drives a central sensitivity-neuropsychiatri...

Abstract Background Racial and ethnic minorities and those with lower incomes are disproportionately affected by chronic kidney disease (CKD). The objectives of this study were to estimate the prevalence of access barrie...

Abstract This study characterizes the seasonal variations and cross-boundary aerosol transport in central Thailand using a combination of low-cost PM2.5 sensors, sunphotometer observations, and Himawari-9 satellite aeros...

Online advertising platforms commonly employ Cost-Per-Click (CPC) and Cost-Per-Thousand-Impressions (CPM) models to determine advertiser fees based on user engagement and exposure metrics. While these pricing arrangement...

Enrico Torre,1 Sergio Di Matteo,2 Chiara Martinotti,2 Giacomo Matteo Bruno,3 Alessandro Cabrino,2 Emma Lucia Fogliati,2 Andrea Giusti,4 Marco Barbieri,5 Luigi Carlo Bottaro,6 Giorgio Lorenzo Colombo3 1Diabetology and Met...

Abstract Background Semaglutide, a glucagon-like peptide-1 receptor agonist, and resmetirom, a thyroid hormone receptor-β agonist, are approved therapies for noncirrhotic metabolic dysfunction–associated steatohepatit...

Abstract Background Obesity is a significant contributor to global morbidity and mortality, driven by rising consumption of unhealthy energy dense foods high in salt, sugar and fat (HFSS). Supermarkets, pivotal in food d...

Abstract The number of electric vehicles has increased due to emission concerns associated with conventional transportation systems. Therefore, the energy management of charging demand has been quite consequential in rec...

This study aimed to compare reimbursement prices for new, innovative non-orphan drugs in Germany based on price negotiation and cost-effectiveness analysis, using the efficiency frontier (EF) approach and cost-utility an...

Abstract Background Adoptive cell therapy with tumour-infiltrating lymphocytes has been recognised as a safe and effective treatment for patients with advanced melanoma. Whether such a novel intervention is cost-effectiv...

BackgroundAccurate detection and monitoring of the oestrous cycle in West African Dwarf (WAD) goats is indispensable for reproductive management. Vaginal cytology is commonly used, but different collection methods may va...

Abstract What is the fundamental economic function of the firm under radical uncertainty? This paper advances a theory of the firm centered on economies of cognition: the systematic reduction in the costs of perception, ...

Abstract Background The ageing and growing population, rising cancer rate, and increased healthcare demand drive higher medical costs. Integrating Artificial Intelligence (AI) into oncology revolutionizes cancer diagnosi...

Fuel Cell Recreational Vehicles (FCRVs) are emerging as a promising sustainable alternative to conventional diesel- and gasoline-powered recreational vehicles. This paper evaluates the financial and technological aspects...

Background: Anaemia prevalence among Southern African children aged 6–23 months was estimated at 65% in 2019. The World Health Organization recommends that children aged 6–23 months living in countries with an anaem...

BackgroundDigital health interventions (DHIs) often struggle with participant engagement. A stepped care approach, starting with low-resource intensity strategies and escalating as needed, can optimize resource use. Yet ...

In this paper, permanent magnet synchronous generators, electrically excited synchronous generators, and hybrid excited synchronous generators are compared to evaluate the difference in performance and cost efficiency fo...

Jeffrey A Thompson,1 Ankita Gupta,2 Julia Catini,3 Pedro A Laires4,5 1Global Health Outcomes and Economics Research, Alexion, AstraZeneca Rare Disease, Boston, MA, USA; 2Optum, New Delhi, India; 3Global Medical Affairs, ...