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Abstract Background Cycas panzhihuaensis, as a national first-class protected plant, has long been threatened by dual high-temperature and drought stress. Photosynthesis is a key target of dual high-temperature and droug...

Abstract Intracerebral hemorrhage (ICH) is a devastating neurological condition with high mortality and morbidity. Despite advancements in medical and surgical treatments, the long-term prognosis of ICH remains poor. Ste...

Abstract Background Cervical cancer remains the fourth most common malignancy among women worldwide, with limited therapeutic success in advanced and recurrent stages. Conventional treatments, including radiotherapy and ...

Abstract Background Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains poorly characterized at the post-transcriptional regulation level. While alternative splicing (AS) perturbations drive...

Ageing is a complex biological process marked by gradual functional decline, reduced cellular resilience, and increased vulnerability to chronic diseases. Maintaining cell health has become a crucial strategy for extendi...

Abstract DNA double-strand break (DSB) represents the most severe form of DNA damage, and both defective and hyperactive repair can compromise genome stability. It is known that blue light promotes DSB repair by cryptoch...

Abstract Aim Periodontitis can impair the osteogenic function of periodontal ligament stem cells (PDLSCs), thereby compromising their capacity for periodontal tissue regeneration. In this study, we explored the impact of...

Abstract The development of safe and effective radioprotective agents with minimal side effects, particularly for high‐dose exposure, remains a global priority. E0703, a novel steroidal compound structurally derived fr...

Abstract Background CS2164 is an oral multi-target inhibitor that targets angiogenesis-related kinases, mitosis-related kinases, and chronic inflammation-related kinases. However, the added clinical benefit of CS2164 com...

N6-methyladenosine (m6A) is a major post-transcriptional RNA modification, and the demethylase ALKBH5 has emerged as a versatile but highly context-dependent regulator of RNA fate. This review integrates current evidence...

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a relevant cancer entity with two main risk factors. Human papilloma virus (HPV)-positive ones are induced by virus infection and generally have a good...

Free radical damage to the body can be prevented and repaired using antioxidants. Various natural ingredients native to Indonesia contain antioxidants, which are needed to improve people's health at an affordable cost. P...

Background: Osteochondroma is the most common benign bone tumour, typically arising from the metaphysis of long bones. While often asymptomatic, osteochondromas can rarely lead to potential vascular complications, partic...

We reveal a coordinating role for Cx32-mediated cell–cell communication in maintaining mitotic-quiescence and limiting migration-associated TGFβ signalling, extracellular matrix remodelling and mesenchymal-like change...

In this study, dopamine (DA) was covalently grafted onto graphene oxide (GO) to form a functionalized nanofiller, onto which calcium ions were subsequently coordinated, yielding GO–PDA–Ca nanocomposites for epoxy coa...

IntroductionAcute pancreatitis (AP) is a severe inflammatory disease where epithelial injury and dysregulated repair are central to pathogenesis, yet the underlying transcriptional mechanisms remain poorly understood.Met...

The precise treatment and dynamic management of traumatic brain injury pose a substantial challenge to the global healthcare sector. This challenge arises not only from the complex and dynamically evolving pathological m...

Abstract A fiber laser was used to perform multiple laser cladding passes on AISI 1045 steel to fabricate SiC particle-reinforced Ni60A alloy coatings. The microstructure and phase composition of the cladding layers were...

ABSTRACT Background: Climate change and widespread environmental degradation have increased the risk of natural hazards in recent decades. Hydrological, meteorological, and climatological disasters have become more frequ...

ABSTRACT Intervertebral disc degeneration (IVDD) is a leading global cause of low back pain, with abnormal mechanical stress being a central contributing factor. However, the molecular mechanisms through which mechanical...

Human health is threatened by exposure to reactive toxins that can damage fundamental biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest and one of the most reactive aldehydes. Fo...

Abstract Prostate cancer continues to impose a significant health burden worldwide and in the United States, with rising incidence, persistent mortality rates, and disparities in both incidence and patient outcomes. Adva...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...