Buscar recursos académicos

Cutaneous lymphatic vessels are essential for maintaining tissue homeostasis and coordinating immune defence, making them vital to skin health. Recent advances in molecular biology and immunology have revealed the associ...

Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

ABSTRACT: Introduction and aims: To provide the research progress on the cGAS-STING signalling pathway and its related roles in various oral diseases. Methods: We reviewed the recent research on cGAS-STING in PubMed. Th...

Abstract Background Proper eating/fasting cycle can regulate circadian rhythms, thereby influencing metabolic regulation, oxidative stress, and cognitive function. However, its association with overall health remains und...

Micronutrients serve as critical metabolic sensors and epigenetic regulators that orchestrate cytokine production through multiple overlapping signalling cascades, transcriptional networks, and cellular metabolic states....

Oxidative stress (OS), derived from an imbalance between reactive oxygen species (ROS) accumulation and impaired antioxidant defense, is a recognized cause of atherothrombosis, through a complex interaction between low-g...

Copper is an essential trace element in the human body, extensively involved in key physiological and biochemical processes such as antioxidant defense, energy metabolism, neural signaling, and immune regulation. In rece...

Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies. Although chronic neuroinflammation and aberrant protein aggregation ar...

ABSTRACT Background Low muscle mass is increasingly recognized to extend beyond aging and is closely linked to metabolic dysfunction. Its population‐level burden, ethnic disparities, metabolic clustering and mortality ...

Oral mucosal ageing represents a fundamental reprogramming of the tissue microenvironment, a dynamic process that underlies the functional decline and heightened disease susceptibility observed in the elderly. This revie...

Abstract Objectives The study aims to address the emerging issue of population ageing in India alongside the rising burden of non-communicable diseases, with a particular focus on the rural-urban differences in diabetes ...

Abstract Background The growing global aging population and the high prevalence of oral diseases among the elderly significantly affect their quality of life. This study aimed to assess the current status of oral health ...

IntroductionThis study aims to explore the relationship between residential context and health-related outcomes. It seeks to analyze the differences in sociodemographic profiles, health status, psychosocial well-being, a...

Abstract Background Despite antiretroviral therapy (ART), people with HIV (PWH) face immunological ageing and accelerated comorbidities including coronary artery disease (CAD). Gut mucosal damage, chronic inflammation, a...

PurposeProlonged QT intervals are clinically relevant in patients with type 2 diabetes mellitus (T2DM). However, accurately detecting the Q and T points in electrocardiogram (ECG) signals remains challenging owing to the...

ABSTRACT Background and Aims Obstructive sleep apnea (OSA) is a prevalent sleep disorder linked to cardiovascular diseases and is highly prevalent, especially in the elderly population. This study aimed to investigate th...

Abstract Background Chronic liver disease (CLD) and heart disease (HD) are major contributors to global morbidity and mortality. Although increasing evidence supports close interactions between the liver and heart, popul...

ABSTRACT Background/Aim Most patients with proteinuria are considered to have typical diabetic nephropathy (DN). However, when proteinuria occurs without diabetic retinopathy, with hematuria, or persists despite strict g...

Bo Lv,1,2,* Zhaoyang Wang,1,* Kai Meng1,2 1School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Tiantan Hospital, Capital Medical University, Beijing, Peopl...

Lysosomal dysfunction is a core pathological driver of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Transcription factor EB (TFEB) serves as a master regulator of lysosomal biogenesis, and its ...

Abstract Aging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders. Here we report in vitro screening outputs from a natural...

The purpose of the review is to analyze the results of scientific research on the effect of antioxidant activity of potatoes on human health, to consider modern approaches to breeding potato with high antioxidant activit...

Abstract Background Heart failure (HF) has high morbidity and mortality, worsened by aging and metabolic diseases. The triglyceride–glucose (TyG) index and its obesity-related derivatives are markers of metabolic dysfu...

Abstract Background Telomere length (TL), a biomarker of biological aging, but its association with Alzheimer’s disease (AD) remains unclear. Methods We estimated TL in whole-genome sequencing data from 35,014 Alzheime...