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Abstract DNA replication timing (RT) often correlates with transcription during cell fate transitions, yet notable exceptions indicate a complex relationship. Using a reductionist system in mouse embryonic stem cells, we...

A single-stranded DNA (ssDNA) virus was detected in Yerba mate samples showing chlorotic linear patterns, chlorotic rings and vein yellowing. The full-genome sequences of six different isolates of this ssDNA circular vir...

Silicosis, caused by inhalation of crystalline silica (SiO2), remains a serious and persistent public health concern. Puerarin (Pue), a bioactive isoflavone derived from Pueraria lobata, is known for its anti-inflammator...

Abstract Bacterial chromosomes are organized by condensins, such as Structural Maintenance of Chromosomes (SMC) proteins. In Streptomyces, a genus of sporulating bacteria, SMC proteins align chromosomal arms and promote ...

Leukemia inhibitory factor (LIF) and oncostatin M (OSM) induce DNA synthesis in Swiss 3T3 cells through common signaling mechanism(s), whereas other related cytokines such as interleukin-6 and ciliary neurotrophic factor...

This study was conducted to evaluate the effect of cottonseed meal supplemented with lysine and enzyme on laying hens performance and egg quality. Eighty Hy-Line W-36 white Leghorns were allotted for 12 weeks in a 2 × 2...

Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...

Brucellosis, a zoonotic disease, triggers severe inflammation and reproductive complications in both humans and animals. The standard treatment protocol relies on prolonged antibiotic courses, often combining streptomyci...

Adenosine deaminase 1-deficient severe combined immune deficiency (ADA-SCID) has widely been attributed to the toxic accumulation of adenine deoxyribonucleotides (dAXP) derived from 2’-deoxyadenosine (dAdo). The presen...

Abstract Objective Intestinal organoids serve as important tools for drug screening, but the extent to which they recapitulate in vivo tissue microenvironments and drug responses remains inadequately evaluated. This s...

S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosyl...

Gut and skin microbiota impact host physiology and can be influenced by environmental changes, however, their reactions to rising environmental temperatures remain unclear. In this study, Bufo gargarizans tadpoles were e...

This study employed hepatic transcriptional changes to catalogue signature genes associated with divergent residual average daily gain (RADG) phenotypes in crossbred beef steers. A total of 108 crossbred beef steers (ave...

Abstract Objective This study aimed to systematically identify and validate KIF15 as a potential diagnostic and prognostic biomarker in colon cancer (CC) using integrated bioinformatics analyses. We further explored its ...

Abstract Objective The predictive value of intratumoral microbiota for the efficacy of neoadjuvant immunochemotherapy, as well as the changes in microbiota before and after treatment, has remained largely unexplored. Me...

Abstract Dysfunction of epithelial cell contacts associates with a myriad of human diseases. Cisplatin is an effective antineoplastic agent where it interferes with DNA replication in proliferating cells, but it causes k...

Abstract The activating signal co-integrator 1 complex subunit 3 (ASCC3), a multifunctional protein, has been implicated as a prognostic marker in several types of cancer. However, mechanisms underlying its prognostic va...

Background: Combined antiretroviral treatment (cART) for HIV infection is highly effective in controlling viral replication. However, it cannot achieve a sterilizing cure. Several strategies have been proposed to achieve...

Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of complications with rising complexity, particularly as EBV-negative forms are increasingly recognized in adult recipients. While earl...

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a DNA virus linked to multiple malignancies associated with compromised immunity, such as Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL). These malignancie...

Background: The bacterial chromosome may be used to stably maintain foreign DNA in the mega-base range. Integration into the chromosome circumvents issues such as plasmid replication, stability, incompatibility, and copy...

Dengue virus is a major global health threat and can lead to life-threatening hemorrhagic complications due to immune activation and cytokine production. Cross-reactive antibodies to an earlier dengue virus infection are...

Circular Rep-encoding single-stranded DNA (CRESS-DNA) virus Rep proteins are multidomain enzymes that mediate viral DNA rolling-circle replication. Reps nick viral DNA to expose a 3' end for polymerase extension, provide...

Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA. Due to the end replication problem, telomeres of somat...