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ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

Persistent cervical human papillomavirus (HPV) infection is the key biological event underlying high-grade squamous intraepithelial lesions, cervical cancer development, and recurrence risk. Botanical drugs and their bio...

ObjectivesSince its inception in 2017, China’s National Drug Price Negotiation (NDPN) has served as a crucial mechanism for the strategic procurement of innovative medicines, with pediatric medicines representing a key...

Invasive fungal infections remain a major cause of global morbidity and mortality, with resistance to conventional antifungal agents posing an increasing challenge. Ethosomal nanocarriers have gained attention as effecti...

Abstract Background Previous studies have indicated potential associations between some drugs and cancer risk, but the causal relationship with gastric cancer remains unclear. This study aimed to explore the causality be...

Objective To characterise temporal trends in antiretroviral therapy (ART) utilisation and forecast short-term changes in regimen distribution within a provincial HIV treatment programme.Design Population-level longitudin...

Artificial saliva (AS) is an aqueous solution designed to mimic the properties of natural saliva and is widely used in various in vitro studies. This investigation aimed to identify the most frequently selected AS compos...

Amphotericin B (AmB) is a potent, accessible, FDA-approved drug against CL with damaging side effects. While newer lipid formulations have less toxicity, limitations include affordability and cold-chain requirements. CL ...

Abstract This study investigates the synthesis and evaluation of glycine-conjugated 5.0G polypropyleneimine dendrimers as an advanced nanocarrier system for the selective delivery of chloroquine. 5.0G PPI dendrimers were...

Abstract Background Naringenin has shown attractive neuroprotective effects; however, it is characterized by low oral bioavailability. Naringenin-loaded nanoparticles (Nar-NPs) were prepared for enhanced delivery, and ...

Herbal medicines have been extensively used for centuries owing to their therapeutic benefits and comparatively low incidence of adverse effects. Despite their clinical potential, the effectiveness of many herbal formula...

Synthesis of new drugs, their rational design, or isolation from natural sources has decreased, and these facts lead to the use of currently marketed drugs. Some of them, extensively used, show unfavorable properties rel...