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The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the loc...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

Xiaoyi Fu,1 Zijian Zhang,1 Qinyi Dong,1 Siying Li,2 Xinman Wang,2 Han Zhang,2 Jiahao Bai,2 Huiyan Han,2 Lei Shi,2 Kaili Zheng,2 Lili Liang2,3 1The Third Clinical College, Shanxi University of Chinese Medicine, Taiyuan, S...

Researchers in pharmacy are paying increasingly close attention to nanogel-based multifunctional drug delivery systems, particularly hybrid nanogels and multicompartment nanogels because they can lead to the achievement ...

Abstract The advancement of sustained-release drug delivery systems is profoundly reshaping the medicinal applications. This study highlights a novel approach to developing sustained-release esterase responsive drug deli...

Two kinds of functionalized nanostructured hybrid microspheres, based on the bridged silsesquioxane family, were synthesized by employing the sol-gel method via self-assembly of two different organic-inorganic bridged mo...

Abstract Background Systemic antibiotic administration requires repeated dosing to maintain therapeutic plasma concentrations. Controlled drug delivery systems reduce the need for continuous systemic antibiotic use by en...

Abstract The Chitosan is a non-toxic, biocompatibale ploysacchride produced by deacetyltion of naturally occurring chitin. The mucoadhesitivity and biodegradability of chitosan have made chitosan as a choice material fo...

Abstract Diabetes mellitus represents one of the most prevalent chronic diseases worldwide, posing serious challenges to global health and healthcare sustainability. Conventional therapeutic strategies often face limitat...

Abstract Curcumin, a natural polyphenol with multifaceted anticancer properties, faces significant clinical translation challenges due to poor solubility, rapid metabolism, and low bioavailability. Hydrogels, as biocompa...

Inorganic materials contain remarkable properties for drug delivery, such as a large surface area and nanoporous structure. Among these materials, CaCO3 microparticles (CMPs) exhibit a high encapsulation efficiency and s...

Films based on biopolymers and loaded with antimicrobial agents are convenient pharmaceutical dosage forms for topical application. Inorganic carriers loaded with these agents lead to composite materials, which combined ...

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

The aim of this Campbell systematic review is to synthesize the extant empirical evidence on the effects of boot‐camps and boot camp like programs on the criminal behavior (e.g., postrelease arrest, conviction, or rein...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Background: The growth of a topical vehicle microemulsions has been more enhanced compared to the normal skin applications such as creams, gels among others. These micro-structured vehicles showed enhanced solubilization...

Abstract Critical-sized bone defects possess inherently limited self-healing potential, posing a persistent challenge in clinical bone repair. In recent years, numerous hydrogel systems have been developed for bone defec...

Abstract Man-made synthetic/manufactured nano-objects (MNOs) are increasingly used in almost every scientific sector, including pharmaceutical, agricultural, food, and drug industries worldwide. Rapid advances in nanotec...

Autoimmune diseases, such as systemic lupus erythematosus (SLE), are complex disorders characterized by an abnormal immune response. In these diseases, the immune system mistakenly identifies different body components as...

This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model dr...

Implants prepared with polymer blends [poly (e-caprolactone)-poly(lactide), PCL-PLA] at different rates were developed from microspheres. Approximately 19% of dexamethasone acetate was encapsulated into the microsphere...

The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. ...

The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class-II model drug. Attempts were made to pre...